Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 4616231..4617452 Replicon chromosome
Accession NZ_CP093016
Organism Pseudomonas aeruginosa strain H15

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MMZ75_RS21635 Protein ID WP_003114949.1
Coordinates 4616231..4616809 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MMZ75_RS21640 Protein ID WP_241474240.1
Coordinates 4616898..4617452 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMZ75_RS21620 (MMZ75_21615) 4611508..4612785 + 1278 WP_003122808.1 TolC family protein -
MMZ75_RS21625 (MMZ75_21620) 4612775..4614946 + 2172 WP_003088105.1 type I secretion system permease/ATPase -
MMZ75_RS21630 (MMZ75_21625) 4614936..4616123 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
MMZ75_RS21635 (MMZ75_21630) 4616231..4616809 - 579 WP_003114949.1 HD domain-containing protein Toxin
MMZ75_RS21640 (MMZ75_21635) 4616898..4617452 - 555 WP_241474240.1 helix-turn-helix transcriptional regulator Antitoxin
MMZ75_RS21645 (MMZ75_21640) 4617610..4619805 - 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
MMZ75_RS21650 (MMZ75_21645) 4619810..4620271 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
MMZ75_RS21655 (MMZ75_21650) 4620602..4620925 + 324 WP_003102734.1 multidrug efflux SMR transporter -
MMZ75_RS21660 (MMZ75_21655) 4620938..4621336 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
MMZ75_RS21665 (MMZ75_21660) 4621333..4621884 - 552 WP_003102727.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-66)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T237550 WP_003114949.1 NZ_CP093016:c4616809-4616231 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T237550 NZ_LR882497:c757013-756705 [Mycobacterium tuberculosis variant microti]
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20480.66 Da        Isoelectric Point: 8.1460

>AT237550 WP_241474240.1 NZ_CP093016:c4617452-4616898 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLYRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT237550 NZ_LR882497:c757236-757000 [Mycobacterium tuberculosis variant microti]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGATGCGGCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References