Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/HTH_10(toxin) |
| Location | 870219..871192 | Replicon | chromosome |
| Accession | NC_012589 | ||
| Organism | Sulfolobus islandicus L.S.2.15 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | C3MNP7 |
| Locus tag | LS215_RS04760 | Protein ID | WP_012713380.1 |
| Coordinates | 870581..871192 (+) | Length | 204 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | D2PHE6 |
| Locus tag | LS215_RS04755 | Protein ID | WP_012713379.1 |
| Coordinates | 870219..870563 (+) | Length | 115 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LS215_RS04715 (LS215_0961) | 865326..865595 | - | 270 | WP_012713372.1 | hypothetical protein | - |
| LS215_RS15685 | 865680..865766 | - | 87 | Protein_992 | IS1 family transposase | - |
| LS215_RS04720 (LS215_0962) | 865913..866383 | - | 471 | WP_012713373.1 | DsrE/DsrF/DrsH-like family protein | - |
| LS215_RS04725 (LS215_0963) | 866608..867222 | + | 615 | WP_012713374.1 | carbonic anhydrase | - |
| LS215_RS04730 (LS215_0964) | 867237..867995 | - | 759 | WP_012713375.1 | hypothetical protein | - |
| LS215_RS04735 (LS215_0965) | 868288..868677 | + | 390 | WP_012713376.1 | CBS domain-containing protein | - |
| LS215_RS04740 (LS215_0966) | 868812..869087 | + | 276 | WP_012713377.1 | hypothetical protein | - |
| LS215_RS04745 (LS215_0967) | 869196..869840 | + | 645 | WP_012713378.1 | IS6 family transposase | - |
| LS215_RS04750 | 869905..870138 | + | 234 | WP_048051881.1 | C2H2-type zinc finger protein | - |
| LS215_RS04755 (LS215_0968) | 870219..870563 | + | 345 | WP_012713379.1 | DUF488 domain-containing protein | Antitoxin |
| LS215_RS04760 (LS215_0969) | 870581..871192 | + | 612 | WP_012713380.1 | helix-turn-helix domain-containing protein | Toxin |
| LS215_RS04765 (LS215_0970) | 871389..872567 | + | 1179 | WP_012713381.1 | amidohydrolase family protein | - |
| LS215_RS04770 (LS215_0971) | 872676..874496 | + | 1821 | WP_012713382.1 | 4Fe-4S binding protein | - |
| LS215_RS04775 (LS215_0972) | 874568..875713 | - | 1146 | WP_012713383.1 | FtsX-like permease family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 204 a.a. Molecular weight: 23124.12 Da Isoelectric Point: 8.9687
>T23755 WP_012713380.1 NC_012589:870581-871192 [Sulfolobus islandicus L.S.2.15]
MYRSPFEVTLLIEDHPCEVMKIISLTGLKASVENVKLGEQTTDHIVSFEKEIEKSEVLKLKSNSVKVLKLSETKVWVRTN
GCVVCRILYTSDVVVEKIKVLKERTLLYTLLVPNSSSFKEFLTKLSKEGVKVTVLNVSEISSAELTERQMEILQLAYKLG
YFNDDRGITLSQLADKLGISAPTLEEILRRALRKVVKYYLDKH
MYRSPFEVTLLIEDHPCEVMKIISLTGLKASVENVKLGEQTTDHIVSFEKEIEKSEVLKLKSNSVKVLKLSETKVWVRTN
GCVVCRILYTSDVVVEKIKVLKERTLLYTLLVPNSSSFKEFLTKLSKEGVKVTVLNVSEISSAELTERQMEILQLAYKLG
YFNDDRGITLSQLADKLGISAPTLEEILRRALRKVVKYYLDKH
Download Length: 612 bp
>T23755 NC_012589:870581-871192 [Sulfolobus islandicus L.S.2.15]
ATGTATAGATCTCCCTTTGAAGTAACATTACTAATAGAGGATCACCCTTGTGAAGTAATGAAAATAATATCATTAACGGG
ACTTAAAGCAAGTGTGGAAAACGTTAAGTTAGGAGAACAAACTACGGACCATATAGTTAGTTTCGAAAAGGAGATAGAGA
AGAGTGAAGTTCTAAAATTAAAGTCAAATAGCGTTAAAGTGCTAAAACTCAGTGAAACTAAAGTATGGGTGAGAACTAAT
GGATGTGTGGTATGCAGGATACTTTATACTTCTGATGTAGTTGTAGAGAAAATTAAAGTACTAAAAGAGAGGACTTTACT
TTATACTTTACTTGTACCTAATAGCTCATCGTTTAAGGAATTTTTAACCAAATTATCGAAAGAAGGAGTAAAAGTAACAG
TTTTAAACGTCTCAGAGATATCTAGTGCGGAACTTACTGAGAGGCAGATGGAAATACTACAATTAGCCTATAAGTTAGGT
TATTTTAATGATGATAGGGGTATTACATTATCTCAGCTAGCAGATAAATTGGGAATAAGTGCGCCAACTCTGGAAGAGAT
ATTAAGGAGAGCTCTCAGAAAAGTTGTTAAGTATTATTTGGATAAGCATTAA
ATGTATAGATCTCCCTTTGAAGTAACATTACTAATAGAGGATCACCCTTGTGAAGTAATGAAAATAATATCATTAACGGG
ACTTAAAGCAAGTGTGGAAAACGTTAAGTTAGGAGAACAAACTACGGACCATATAGTTAGTTTCGAAAAGGAGATAGAGA
AGAGTGAAGTTCTAAAATTAAAGTCAAATAGCGTTAAAGTGCTAAAACTCAGTGAAACTAAAGTATGGGTGAGAACTAAT
GGATGTGTGGTATGCAGGATACTTTATACTTCTGATGTAGTTGTAGAGAAAATTAAAGTACTAAAAGAGAGGACTTTACT
TTATACTTTACTTGTACCTAATAGCTCATCGTTTAAGGAATTTTTAACCAAATTATCGAAAGAAGGAGTAAAAGTAACAG
TTTTAAACGTCTCAGAGATATCTAGTGCGGAACTTACTGAGAGGCAGATGGAAATACTACAATTAGCCTATAAGTTAGGT
TATTTTAATGATGATAGGGGTATTACATTATCTCAGCTAGCAGATAAATTGGGAATAAGTGCGCCAACTCTGGAAGAGAT
ATTAAGGAGAGCTCTCAGAAAAGTTGTTAAGTATTATTTGGATAAGCATTAA
Antitoxin
Download Length: 115 a.a. Molecular weight: 13670.94 Da Isoelectric Point: 9.9999
>AT23755 WP_012713379.1 NC_012589:870219-870563 [Sulfolobus islandicus L.S.2.15]
MIKVKRVYDPLEKDDGIRILVDRLWPRGVKKDQVDVWLKDIAPSDELRKWYNHDPNKWEEFKRKYFEELSRNPKVEILLQ
LIKKGNNVTLLYASKSPYNNAVALKEYLEKVLKV
MIKVKRVYDPLEKDDGIRILVDRLWPRGVKKDQVDVWLKDIAPSDELRKWYNHDPNKWEEFKRKYFEELSRNPKVEILLQ
LIKKGNNVTLLYASKSPYNNAVALKEYLEKVLKV
Download Length: 345 bp
>AT23755 NC_012589:870219-870563 [Sulfolobus islandicus L.S.2.15]
ATGATAAAAGTTAAGAGAGTTTACGATCCTTTAGAAAAGGATGATGGAATTAGGATTTTAGTAGACAGATTATGGCCTAG
AGGTGTTAAGAAGGATCAAGTAGACGTTTGGCTTAAGGACATAGCACCTAGTGATGAACTAAGGAAATGGTATAATCACG
ATCCTAACAAATGGGAGGAGTTTAAAAGGAAGTACTTTGAGGAACTCAGTAGAAATCCTAAGGTTGAAATACTCTTACAG
TTAATTAAAAAGGGGAATAATGTAACCTTACTTTATGCCTCAAAATCTCCATATAATAATGCGGTGGCATTAAAAGAGTA
TTTAGAGAAGGTATTAAAGGTTTGA
ATGATAAAAGTTAAGAGAGTTTACGATCCTTTAGAAAAGGATGATGGAATTAGGATTTTAGTAGACAGATTATGGCCTAG
AGGTGTTAAGAAGGATCAAGTAGACGTTTGGCTTAAGGACATAGCACCTAGTGATGAACTAAGGAAATGGTATAATCACG
ATCCTAACAAATGGGAGGAGTTTAAAAGGAAGTACTTTGAGGAACTCAGTAGAAATCCTAAGGTTGAAATACTCTTACAG
TTAATTAAAAAGGGGAATAATGTAACCTTACTTTATGCCTCAAAATCTCCATATAATAATGCGGTGGCATTAAAAGAGTA
TTTAGAGAAGGTATTAAAGGTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|