Detailed information of TA system TA237549

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 3674515..3675773
• Replicon: chromosome
• Accession: NZ_CP093016
• Organism: Pseudomonas aeruginosa strain H15

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MMZ75_RS17180
• Protein ID: WP_003123189.1
• Coordinates: 3675018..3675773 (+)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: MMZ75_RS17175
• Protein ID: WP_003086329.1
• Coordinates: 3674515..3674883 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMZ75_RS17155 (MMZ75_17150)	3670678..3670953	+	276	WP_173014646.1	zinc ribbon domain-containing protein	-
MMZ75_RS17160 (MMZ75_17155)	3670956..3671432	-	477	WP_003112531.1	hypothetical protein	-
MMZ75_RS17165 (MMZ75_17160)	3671511..3673100	+	1590	WP_003123191.1	aldehyde dehydrogenase family protein	-
MMZ75_RS17170 (MMZ75_17165)	3673156..3674442	+	1287	WP_003123190.1	FAD-binding oxidoreductase	-
MMZ75_RS17175 (MMZ75_17170)	3674515..3674883	+	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
MMZ75_RS17180 (MMZ75_17175)	3675018..3675773	+	756	WP_003123189.1	RES family NAD+ phosphorylase	Toxin
MMZ75_RS17185 (MMZ75_17180)	3676541..3677902	+	1362	WP_003081943.1	DNA recombination protein RmuC	-
MMZ75_RS17190 (MMZ75_17185)	3678057..3680600	-	2544	WP_003123188.1	acyl-homoserine-lactone acylase QuiP	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28267.46 Da
• Isoelectric Point: 8.3428

>T237549 WP_003123189.1 NZ_CP093016:3675018-3675773 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGMRLQAPPFSDHEAALTDIA
DYRAPQKLGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T237549 NZ_LR882497:c755387-755004 [Mycobacterium tuberculosis variant microti]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT237549 WP_003086329.1 NZ_CP093016:3674515-3674883 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT237549 NZ_LR882497:c755637-755482 [Mycobacterium tuberculosis variant microti]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Structures

Antitoxin

• AlphaFold DB: V6AJU7