Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 3357254..3357862 Replicon chromosome
Accession NZ_CP093016
Organism Pseudomonas aeruginosa strain H15

Toxin (Protein)


Gene name PfiT Uniprot ID A0A1B1XUZ2
Locus tag MMZ75_RS15595 Protein ID WP_003123043.1
Coordinates 3357515..3357862 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag MMZ75_RS15590 Protein ID WP_003114155.1
Coordinates 3357254..3357505 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMZ75_RS15560 (MMZ75_15555) 3352893..3353162 - 270 WP_078451377.1 hypothetical protein -
MMZ75_RS15565 (MMZ75_15560) 3353280..3353495 + 216 WP_003123047.1 hypothetical protein -
MMZ75_RS15570 (MMZ75_15565) 3353518..3353733 + 216 WP_003123046.1 hypothetical protein -
MMZ75_RS15575 (MMZ75_15570) 3353726..3354115 + 390 WP_031687489.1 hypothetical protein -
MMZ75_RS15580 (MMZ75_15575) 3354765..3356057 + 1293 WP_003123045.1 hypothetical protein -
MMZ75_RS15585 (MMZ75_15580) 3356057..3357040 + 984 WP_003123044.1 tyrosine-type recombinase/integrase -
MMZ75_RS15590 (MMZ75_15585) 3357254..3357505 + 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MMZ75_RS15595 (MMZ75_15590) 3357515..3357862 + 348 WP_003123043.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MMZ75_RS15605 (MMZ75_15600) 3358189..3359091 - 903 WP_003123042.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
MMZ75_RS15610 (MMZ75_15605) 3359542..3360279 - 738 WP_003085453.1 murein L,D-transpeptidase catalytic domain family protein -
MMZ75_RS15615 (MMZ75_15610) 3360359..3361402 - 1044 WP_003098363.1 L,D-transpeptidase -
MMZ75_RS15620 (MMZ75_15615) 3361538..3362230 - 693 WP_003098362.1 16S rRNA pseudouridine(516) synthase -
MMZ75_RS15625 (MMZ75_15620) 3362230..3362502 - 273 WP_003120794.1 cysteine-rich CWC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3347909..3357862 9953


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12990.74 Da        Isoelectric Point: 4.4212

>T237548 WP_003123043.1 NZ_CP093016:3357515-3357862 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T237548 NZ_LR882497:719769-720176 [Mycobacterium tuberculosis variant microti]
GTGAGCACGACGCCGGCCGCCGGAGTGCTCGACACGTCGGTGTTCATCGCGACCGAAAGCGGCCGGCAACTCGACGAGGC
GCTGATCCCCGACCGGGTCGCCACCACCGTCGTCACCCTCGCCGAACTGCGCGTCGGCGTGCTGGCCGCGGCGACGACCG
ACATCCGGGCTCAACGCCTGGCGACCCTGGAATCCGTTGCCGATATGGAAACGTTGCCCGTCGACGACGATGCCGCCCGA
ATGTGGGCCCGATTGCGGATCCATCTTGCCGAGTCCGGTCGCCGGGTGCGGATCAACGACCTGTGGATCGCGGCCGTCGC
GGCATCGCGAGCGCTGCCGGTCATCACCCAGGACGACGACTTCGCCGCCCTCGACGGTGCGGCCAGTGTGGAGATCATTC
GGGTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT237548 WP_003114155.1 NZ_CP093016:3357254-3357505 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT237548 NZ_LR882497:719512-719772 [Mycobacterium tuberculosis variant microti]
ATGTCTGAGGTGGCCTCGCGTGAGCTGCGTAACGATACGGCCGGCGTGCTGCGCCGCGTGCGGGCAGGGGAGGACGTCAC
CATCACCGTCAGCGGCCGTCCGGTCGCGGTGCTTACCCCGGTTCGTCCGCGGCGCCGGCGTTGGCTGAGCAAAACGGAGT
TCCTGTCGCGGTTGCGCGGCGCTCAAGCCGATCCCGGGCTCCGTAACGACCTCGCGGTCCTTGCCGGCGACACGACCGAG
GATCTCGGGCCGATCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1XUZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References