Detailed information of TA system TA237546

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1420361..1420866
• Replicon: chromosome
• Accession: NZ_CP093016
• Organism: Pseudomonas aeruginosa strain H15

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A069QL22
• Locus tag: MMZ75_RS06635
• Protein ID: WP_003121619.1
• Coordinates: 1420585..1420866 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q9I707
• Locus tag: MMZ75_RS06630
• Protein ID: WP_003112628.1
• Coordinates: 1420361..1420588 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMZ75_RS06605 (MMZ75_06605)	1415379..1416872	+	1494	WP_031653061.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-
MMZ75_RS06610 (MMZ75_06610)	1417041..1418468	+	1428	WP_003121620.1	GABA permease	-
MMZ75_RS06615 (MMZ75_06615)	1418550..1418891	-	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
MMZ75_RS06620 (MMZ75_06620)	1418964..1419464	-	501	WP_003112629.1	LEA type 2 family protein	-
MMZ75_RS06625 (MMZ75_06625)	1419565..1420185	+	621	WP_003101226.1	hypothetical protein	-
MMZ75_RS06630 (MMZ75_06630)	1420361..1420588	+	228	WP_003112628.1	CopG family ribbon-helix-helix protein	Antitoxin
MMZ75_RS06635 (MMZ75_06635)	1420585..1420866	+	282	WP_003121619.1	type II toxin-antitoxin system toxin ParE	Toxin
MMZ75_RS06640 (MMZ75_06640)	1421166..1422074	+	909	WP_003083769.1	LysR family transcriptional regulator	-
MMZ75_RS06645 (MMZ75_06645)	1422106..1422516	-	411	WP_003101225.1	aegerolysin family protein	-
MMZ75_RS06650 (MMZ75_06650)	1422696..1423430	-	735	WP_003117208.1	GntR family transcriptional regulator	-
MMZ75_RS06655 (MMZ75_06655)	1423531..1424217	-	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
MMZ75_RS06660 (MMZ75_06660)	1424266..1425615	-	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10492.22 Da
• Isoelectric Point: 10.0435

>T237546 WP_003121619.1 NZ_CP093016:1420585-1420866 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T237546 NZ_LR882497:712492-712893 [Mycobacterium tuberculosis variant microti]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8568.64 Da
• Isoelectric Point: 5.5740

>AT237546 WP_003112628.1 NZ_CP093016:1420361-1420588 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT237546 NZ_LR882497:712268-712495 [Mycobacterium tuberculosis variant microti]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGTCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Structures

Toxin

• AlphaFold DB: A0A069QL22

Antitoxin

• AlphaFold DB: Q9I707