Detailed information of TA system TA237537

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 143248..143753
• Replicon: chromosome
• Accession: NZ_CP093015
• Organism: Pseudomonas aeruginosa strain H16

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: MMZ76_RS00655
• Protein ID: WP_003083773.1
• Coordinates: 143248..143529 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A0H2ZJU8
• Locus tag: MMZ76_RS00660
• Protein ID: WP_003137009.1
• Coordinates: 143526..143753 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMZ76_RS00630 (MMZ76_00630)	138499..139848	+	1350	WP_003137006.1	C4-dicarboxylate transporter DctA	-
MMZ76_RS00635 (MMZ76_00635)	139897..140583	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
MMZ76_RS00640 (MMZ76_00640)	140684..141418	+	735	WP_003110658.1	GntR family transcriptional regulator	-
MMZ76_RS00645 (MMZ76_00645)	141598..142008	+	411	WP_003110659.1	aegerolysin family protein	-
MMZ76_RS00650 (MMZ76_00650)	142040..142948	-	909	WP_003083769.1	LysR family transcriptional regulator	-
MMZ76_RS00655 (MMZ76_00655)	143248..143529	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
MMZ76_RS00660 (MMZ76_00660)	143526..143753	-	228	WP_003137009.1	CopG family ribbon-helix-helix protein	Antitoxin
MMZ76_RS00665 (MMZ76_00665)	143929..144552	-	624	WP_003137011.1	hypothetical protein	-
MMZ76_RS00670 (MMZ76_00670)	144653..145153	+	501	WP_033969777.1	LEA type 2 family protein	-
MMZ76_RS00675 (MMZ76_00675)	145226..145567	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
MMZ76_RS00680 (MMZ76_00680)	145649..147076	-	1428	WP_003083784.1	GABA permease	-
MMZ76_RS00685 (MMZ76_00685)	147245..148738	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T237537 WP_003083773.1 NZ_CP093015:c143529-143248 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T237537 NZ_LR882497:71909-72310 [Mycobacterium tuberculosis variant microti]
GTGGATGAATGTGTAGTCGACGCGGCGGCCGTGGTTGACGCTCTCGCCGGCAAGGGCGCCAGCGCGATCGTTCTGCGCGG
TTTGCTCAAGGAGTCGATTTCTAACGCGCCGCATTTGCTGGACGCAGAGGTCGGACATGCACTCCGCCGCGCCGTGCTCA
GCGACGAAATCTCCGAAGAGCAGGCTCGCGCCGCGTTGGATGCCTTGCCTTATCTCATCGACAATCGTTACCCGCACAGC
CCACGACTGATCGAATACACATGGCAGCTAAGGCACAACGTCACGTTCTACGACGCCCTTTACGTCGCACTGGCCACCGC
ACTGGATGTCCCGCTGCTCACGGGCGACTCGCGGCTTGCGGCCGCGCCGGGCCTTCCGTGCGAAATCAAACTCGTTCGGT
GA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8526.56 Da
• Isoelectric Point: 5.5740

>AT237537 WP_003137009.1 NZ_CP093015:c143753-143526 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHAEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT237537 NZ_LR882497:71677-71916 [Mycobacterium tuberculosis variant microti]
ATGGCTACCATTCAAGTTCGGGATTTGCCCGAAGATGTCGCCGAAACCTATCGACGGCGCGCCACCGCAGCGGGGCAGTC
GCTGCAGACGTATATGCGCACCAAGCTCATCGAAGGGGTGCGGGGCCGAGACAAGGCCGAGGCAATCGAGATCCTGGAAC
AGGCGCTCGCCAGCACTGCCAGCCCAGGCATCAGCCGGGAGACCATCGAGGCATCCCGGCGGGAGCTCAGGGGTGGATGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A0H2ZJU8