Detailed information of TA system TA237535

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4489857..4491115
• Replicon: chromosome
• Accession: NZ_CP093014
• Organism: Pseudomonas aeruginosa strain H17

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MMZ77_RS20590
• Protein ID: WP_003163133.1
• Coordinates: 4489857..4490612 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: MMZ77_RS20595
• Protein ID: WP_003086329.1
• Coordinates: 4490747..4491115 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMZ77_RS20580 (MMZ77_20585)	4485029..4487572	+	2544	WP_003163132.1	acyl-homoserine-lactone acylase QuiP	-
MMZ77_RS20585 (MMZ77_20590)	4487727..4489088	-	1362	WP_003081943.1	DNA recombination protein RmuC	-
MMZ77_RS20590 (MMZ77_20595)	4489857..4490612	-	756	WP_003163133.1	RES family NAD+ phosphorylase	Toxin
MMZ77_RS20595 (MMZ77_20600)	4490747..4491115	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
MMZ77_RS20600 (MMZ77_20605)	4491188..4492474	-	1287	WP_003163134.1	FAD-binding oxidoreductase	-
MMZ77_RS20605 (MMZ77_20610)	4492530..4494119	-	1590	WP_003123191.1	aldehyde dehydrogenase family protein	-
MMZ77_RS20610 (MMZ77_20615)	4494198..4494674	+	477	WP_003163135.1	hypothetical protein	-
MMZ77_RS20615 (MMZ77_20620)	4494677..4494952	-	276	WP_010792073.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28250.37 Da
• Isoelectric Point: 7.7294

>T237535 WP_003163133.1 NZ_CP093014:c4490612-4489857 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T237535 NZ_LR882496:c3773515-3773123 [Mycobacterium tuberculosis variant microti]
ATGGCGGCCATCTATCTCGACTCGTCCGCGATCGTCAAGCTCGCGGTTCGCGAGCCAGAGTCGGACGCGCTGCGCCGCTA
CCTTCGCACCCGCCACCCGCGAGTGTCGAGTGCCCTTGCGCGCGCGGAGGTCATGCGGGCCCTGCTTGACAAGGGTGAAT
CAGCGCGGAAAGCCGGCCGCCGGGCGCTGGCTCATCTCGATCTGCTGCGCGTCGACAAGCGCGTCCTCGATCTCGCTGGT
GGGCTGCTGCCATTCGAGCTGCGCACGCTCGATGCCATCCACTTGGCGACGGCGCAGCGGCTCGGCGTCGATCTGGGCCG
GTTGTGCACCTACGACGACCGGATGCGCGACGCCGCCAAGACGCTCGGCATGGCCGTGATCGCCCCGTCGTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT237535 WP_003086329.1 NZ_CP093014:c4491115-4490747 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT237535 NZ_LR882496:c3773790-3773515 [Mycobacterium tuberculosis variant microti]
ATGACCTCGGTGGGGGTGCGTGCGCTGCGGCAGCGGGCCAGCGAGCTGCTGCGCCGAGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGCGGCCGGCCCGTCGCCCTGCTCTCGCCGCTGCCGCAGGGCGGTCCATACGAGCAGCTGCTGGCAAGCG
GCGAGATCGAGCGTGCCACGCTCGACGTCGTTGATCTGCCCGAACCGCTCGACCTCGACGCGGGCGTCGAGCTGCCGTCG
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA

Structures

Antitoxin

• AlphaFold DB: V6AJU7