237534

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3530623..3531844 Replicon chromosome
Accession NZ_CP093014
Organism Pseudomonas aeruginosa strain H17

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MMZ77_RS16090 Protein ID WP_003162864.1
Coordinates 3531266..3531844 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MMZ77_RS16085 Protein ID WP_003088112.1
Coordinates 3530623..3531177 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMZ77_RS16060 (MMZ77_16065) 3526189..3526740 + 552 WP_003102727.1 XRE family transcriptional regulator -
MMZ77_RS16065 (MMZ77_16070) 3526737..3527135 - 399 WP_128664329.1 NADH-quinone oxidoreductase subunit A -
MMZ77_RS16070 (MMZ77_16075) 3527148..3527471 - 324 WP_003162861.1 multidrug efflux SMR transporter -
MMZ77_RS16075 (MMZ77_16080) 3527804..3528265 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
MMZ77_RS16080 (MMZ77_16085) 3528270..3530465 + 2196 WP_003162863.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
MMZ77_RS16085 (MMZ77_16090) 3530623..3531177 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
MMZ77_RS16090 (MMZ77_16095) 3531266..3531844 + 579 WP_003162864.1 HD domain-containing protein Toxin
MMZ77_RS16095 (MMZ77_16100) 3531952..3533139 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
MMZ77_RS16100 (MMZ77_16105) 3533129..3535300 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
MMZ77_RS16105 (MMZ77_16110) 3535290..3536567 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21911.78 Da        Isoelectric Point: 5.3655

>T237534 WP_003162864.1 NZ_CP093014:3531266-3531844 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDILRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T237534 NZ_LR882496:3746272-3746529 [Mycobacterium tuberculosis variant microti]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT237534 WP_003088112.1 NZ_CP093014:3530623-3531177 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT237534 NZ_LR882496:3746000-3746275 [Mycobacterium tuberculosis variant microti]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References