Detailed information of TA system TA237530

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4446114..4447371
• Replicon: chromosome
• Accession: NZ_CP093012
• Organism: Pseudomonas aeruginosa strain H20

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MM141_RS20670
• Protein ID: WP_003449003.1
• Coordinates: 4446114..4446869 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: MM141_RS20675
• Protein ID: WP_003086329.1
• Coordinates: 4447003..4447371 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MM141_RS20660 (MM141_20670)	4441287..4443830	+	2544	WP_009876046.1	acyl-homoserine-lactone acylase QuiP	-
MM141_RS20665 (MM141_20675)	4443985..4445346	-	1362	WP_003081943.1	DNA recombination protein RmuC	-
MM141_RS20670 (MM141_20680)	4446114..4446869	-	756	WP_003449003.1	RES family NAD+ phosphorylase	Toxin
MM141_RS20675 (MM141_20685)	4447003..4447371	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
MM141_RS20680 (MM141_20690)	4447444..4448730	-	1287	WP_009876045.1	FAD-binding oxidoreductase	-
MM141_RS20685 (MM141_20695)	4448786..4450375	-	1590	WP_003123191.1	aldehyde dehydrogenase family protein	-
MM141_RS20690 (MM141_20700)	4450454..4450930	+	477	WP_003112531.1	hypothetical protein	-
MM141_RS20695 (MM141_20705)	4450933..4451208	-	276	WP_172043275.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28292.45 Da
• Isoelectric Point: 7.7294

>T237530 WP_003449003.1 NZ_CP093012:c4446869-4446114 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T237530 NZ_LR882496:3166984-3167247 [Mycobacterium tuberculosis variant microti]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT237530 WP_003086329.1 NZ_CP093012:c4447371-4447003 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT237530 NZ_LR882496:3166699-3166980 [Mycobacterium tuberculosis variant microti]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA

Structures

Antitoxin

• AlphaFold DB: V6AJU7