Detailed information of TA system TA237529

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3520908..3522129
• Replicon: chromosome
• Accession: NZ_CP093012
• Organism: Pseudomonas aeruginosa strain H20

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C7CS07
• Locus tag: MM141_RS16325
• Protein ID: WP_003102740.1
• Coordinates: 3521551..3522129 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MM141_RS16320
• Protein ID: WP_003088112.1
• Coordinates: 3520908..3521462 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MM141_RS16295 (MM141_16305)	3516476..3517027	+	552	WP_003102727.1	XRE family transcriptional regulator	-
MM141_RS16300 (MM141_16310)	3517024..3517422	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
MM141_RS16305 (MM141_16315)	3517435..3517758	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
MM141_RS16310 (MM141_16320)	3518089..3518550	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
MM141_RS16315 (MM141_16325)	3518555..3520750	+	2196	WP_004349295.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
MM141_RS16320 (MM141_16330)	3520908..3521462	+	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
MM141_RS16325 (MM141_16335)	3521551..3522129	+	579	WP_003102740.1	HD domain-containing protein	Toxin
MM141_RS16330 (MM141_16340)	3522238..3523425	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
MM141_RS16335 (MM141_16345)	3523415..3525586	-	2172	WP_009876279.1	type I secretion system permease/ATPase	-
MM141_RS16340 (MM141_16350)	3525576..3526853	-	1278	WP_009876278.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21869.70 Da
• Isoelectric Point: 5.3655

>T237529 WP_003102740.1 NZ_CP093012:3521551-3522129 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T237529 NZ_LR882496:c3126175-3125783 [Mycobacterium tuberculosis variant microti]
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGTCATCGGCACCCACGACCGGTCACCGTCTGGTAG

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT237529 WP_003088112.1 NZ_CP093012:3520908-3521462 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT237529 NZ_LR882496:c3126387-3126172 [Mycobacterium tuberculosis variant microti]
ATGACCGCTACGGAGGTGAAGGCGAAGATCCTCTCCTTGCTTGATGAAGTGGCCCAGGGCGAGGAGATCGAGATCACCAA
ACACGGCCGCACCGTGGCCCGGCTGGTGGCAGCGACGGGGCCGCACGCGCTGAAGGGTCGATTCTCGGGTGTGGCGATGG
CGGCCGTGGATGACGACGAACTCTTCACCACCGGGGTTTCGTGGAACGTTTCATGA

Structures

Toxin

• AlphaFold DB: A0A0C7CS07