Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1409633..1410290 Replicon chromosome
Accession NZ_CP093012
Organism Pseudomonas aeruginosa strain H20

Toxin (Protein)


Gene name hicA Uniprot ID A0A8G3IXE4
Locus tag MM141_RS06660 Protein ID WP_003098540.1
Coordinates 1410108..1410290 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MM141_RS06655 Protein ID WP_004351284.1
Coordinates 1409633..1410061 (-) Length 143 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MM141_RS06620 (MM141_06620) 1405266..1406015 - 750 WP_223198354.1 XRE family transcriptional regulator -
MM141_RS06625 (MM141_06625) 1406591..1407352 + 762 WP_004351288.1 helix-turn-helix domain-containing protein -
MM141_RS06630 (MM141_06630) 1407349..1408032 + 684 WP_052308356.1 replication protein P -
MM141_RS06635 (MM141_06635) 1408029..1408235 + 207 WP_023109401.1 hypothetical protein -
MM141_RS06640 (MM141_06640) 1408232..1408813 + 582 WP_043884818.1 recombination protein NinG -
MM141_RS06645 (MM141_06645) 1408810..1409106 + 297 WP_024082446.1 hypothetical protein -
MM141_RS06650 (MM141_06650) 1409108..1409482 + 375 WP_004351286.1 antiterminator Q family protein -
MM141_RS06655 (MM141_06655) 1409633..1410061 - 429 WP_004351284.1 hypothetical protein Antitoxin
MM141_RS06660 (MM141_06660) 1410108..1410290 - 183 WP_003098540.1 type II toxin-antitoxin system HicA family toxin Toxin
MM141_RS06665 (MM141_06665) 1410491..1410805 + 315 WP_015649339.1 phage holin, lambda family -
MM141_RS06670 (MM141_06670) 1410805..1411422 + 618 WP_012613700.1 glycoside hydrolase family 19 protein -
MM141_RS06675 (MM141_06675) 1411443..1411892 + 450 WP_024082447.1 lysis system i-spanin subunit Rz -
MM141_RS06680 (MM141_06680) 1411889..1412632 + 744 WP_012613702.1 hypothetical protein -
MM141_RS06685 (MM141_06685) 1412752..1413297 + 546 WP_023083814.1 terminase small subunit -
MM141_RS06690 (MM141_06690) 1413269..1415245 + 1977 WP_004351278.1 phage terminase large subunit family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1395908..1435123 39215


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(7-78)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6746.86 Da        Isoelectric Point: 11.0775

>T237527 WP_003098540.1 NZ_CP093012:c1410290-1410108 [Pseudomonas aeruginosa]
MKFSEFRRWLKAQGVTFEAGKGSHFKITAPNGKQTTFADHGAKEMPEPTRKAIIKQLGLK

Download         Length: 183 bp

>T237527 NZ_LR882496:c3101195-3100839 [Mycobacterium tuberculosis variant microti]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin


Download         Length: 143 a.a.        Molecular weight: 15756.94 Da        Isoelectric Point: 4.6562

>AT237527 WP_004351284.1 NZ_CP093012:c1410061-1409633 [Pseudomonas aeruginosa]
MYDYAIRFEQDDSAPGVAVFCRDLPELNSYGDDKVHAIGEAVDAIESTLSLYVDQRREIPAASQAQPGERVIHLPAVTVA
KIALWNEMVRRDMRKADLCRLLGIAQTQGDRLVDFLHNTKMEAMENALSALGLRLSVNIEAA

Download         Length: 429 bp

>AT237527 NZ_LR882496:c3101409-3101179 [Mycobacterium tuberculosis variant microti]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References