Detailed information of TA system TA237526

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 141136..141641
• Replicon: chromosome
• Accession: NZ_CP093012
• Organism: Pseudomonas aeruginosa strain H20

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A7M2ZNP4
• Locus tag: MM141_RS00640
• Protein ID: WP_009875660.1
• Coordinates: 141136..141417 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A0H2ZJU8
• Locus tag: MM141_RS00645
• Protein ID: WP_003137009.1
• Coordinates: 141414..141641 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MM141_RS00615 (MM141_00615)	136387..137736	+	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-
MM141_RS00620 (MM141_00620)	137785..138471	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
MM141_RS00625 (MM141_00625)	138572..139306	+	735	WP_003110658.1	GntR family transcriptional regulator	-
MM141_RS00630 (MM141_00630)	139486..139896	+	411	WP_009875659.1	aegerolysin family protein	-
MM141_RS00635 (MM141_00635)	139928..140836	-	909	WP_003083769.1	LysR family transcriptional regulator	-
MM141_RS00640 (MM141_00640)	141136..141417	-	282	WP_009875660.1	type II toxin-antitoxin system toxin ParE	Toxin
MM141_RS00645 (MM141_00645)	141414..141641	-	228	WP_003137009.1	CopG family ribbon-helix-helix protein	Antitoxin
MM141_RS00650 (MM141_00650)	141817..142437	-	621	WP_023086863.1	hypothetical protein	-
MM141_RS00655 (MM141_00655)	142538..143038	+	501	WP_003101228.1	LEA type 2 family protein	-
MM141_RS00660 (MM141_00660)	143111..143452	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
MM141_RS00665 (MM141_00665)	143534..144961	-	1428	WP_003083784.1	GABA permease	-
MM141_RS00670 (MM141_00670)	145130..146623	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10461.25 Da
• Isoelectric Point: 10.4670

>T237526 WP_009875660.1 NZ_CP093012:c141417-141136 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLKRWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T237526 NZ_LR882496:c3061955-3061560 [Mycobacterium tuberculosis variant microti]
GTGATCGTCGATACGTCGGCCATCGTCGCCATCGTGAGCGGGGAATCGGGCGCGCAGGTGCTCAAGGAGGCGCTGGAGCG
GTCACCGAACTCCCGAATGTCCGCGCCCAACTACGTCGAACTGTGCGCGATCATGCAGCGGCGGGACCGGCCGGAGATCT
CTCGATTGGTGGACCGTTTGCTGGACGACTACGGAATCCAGGTCGAAGCCGTCGACGCCGACCAAGCCCGCGTGGCCGCG
CAGGCGTATCGCGACTACGGCCGCGGCAGCGGCCATCCGGCCCGTCTCAACCTCGGCGACACCTACAGCTACGCCCTGGC
CCAGGTCACCGGGGAGCCGCTGCTGTTTCGTGGCGATGACTTCACGCATACCGATATCCGGCCCGCGTGCACCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8526.56 Da
• Isoelectric Point: 5.5740

>AT237526 WP_003137009.1 NZ_CP093012:c141641-141414 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHAEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT237526 NZ_LR882496:c3061534-3061268 [Mycobacterium tuberculosis variant microti]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA

Structures

Toxin

• AlphaFold DB: A0A7M2ZNP4

Antitoxin

• AlphaFold DB: A0A0H2ZJU8