Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5123487..5124322 Replicon chromosome
Accession NZ_CP093011
Organism Escherichia coli strain 131

Toxin (Protein)


Gene name yeeV Uniprot ID A0A376WVB1
Locus tag LJF86_RS25030 Protein ID WP_001094448.1
Coordinates 5123487..5123864 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3T7EC32
Locus tag LJF86_RS25035 Protein ID WP_024175935.1
Coordinates 5123954..5124322 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF86_RS25005 (5119042) 5119042..5120280 - 1239 WP_000004159.1 macrolide resistance MFS transporter Mrx(A) -
LJF86_RS25010 (5120277) 5120277..5121182 - 906 WP_000219391.1 Mph(A) family macrolide 2'-phosphotransferase -
LJF86_RS25015 (5121868) 5121868..5122713 - 846 WP_001576423.1 DUF4942 domain-containing protein -
LJF86_RS25020 (5122798) 5122798..5122990 - 193 Protein_4925 hypothetical protein -
LJF86_RS25025 (5123002) 5123002..5123490 - 489 WP_000761714.1 DUF5983 family protein -
LJF86_RS25030 (5123487) 5123487..5123864 - 378 WP_001094448.1 TA system toxin CbtA family protein Toxin
LJF86_RS25035 (5123954) 5123954..5124322 - 369 WP_024175935.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LJF86_RS25040 (5124396) 5124396..5124617 - 222 WP_000692346.1 DUF987 domain-containing protein -
LJF86_RS25045 (5124686) 5124686..5125162 - 477 WP_001618155.1 RadC family protein -
LJF86_RS25050 (5125174) 5125174..5125659 - 486 WP_000214415.1 antirestriction protein -
LJF86_RS25055 (5125751) 5125751..5126569 - 819 WP_001234753.1 DUF932 domain-containing protein -
LJF86_RS25060 (5126660) 5126660..5126893 - 234 WP_001117568.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn aadA5 / qacE / sul1 / mph(A) - 5112792..5121182 8390


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14221.22 Da        Isoelectric Point: 8.2919

>T237525 WP_001094448.1 NZ_CP093011:c5123864-5123487 [Escherichia coli]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T237525 NZ_LR882496:c3061271-3060855 [Mycobacterium tuberculosis variant microti]
ATGACCACGCGCTATTTGCTCGACAAATCAGCGGCTTACCGCGCGCACTTGCCCGCGGTCCGACATCGCTTGGAACCGTT
GATGGAACGCGGTCTACTGGCCCGGTGCGGCATTACCGATCTCGAGTTCGGAGTCTCGGCGCGTTCCCGCGAGGACCATC
GAACACTGGGCACCTACCGGCGTGACGCGCTCGAATACGTCAACACCCCCGACACCGTGTGGGTTCGTGCATGGGAGATC
CAAGAAGCATTGACCGACAAGGGATTTCACCGCTCGGTCAAGATCCCGGACTTGATCATTGCGGCGGTCGCCGAGCATCA
CGGCATACCCGTCATGCACTACGACCAAGACTTCGAACGCATCGCCGCCATCACACGGCAACCCGTGGAATGGGTGGTGG
CCCCAGGGACAGCGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13598.40 Da        Isoelectric Point: 6.6255

>AT237525 WP_024175935.1 NZ_CP093011:c5124322-5123954 [Escherichia coli]
VSDTLSGTTHPDDNDDRLWWGLPCTVTPCFGARLVQKGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT237525 NZ_LR882496:c3061534-3061268 [Mycobacterium tuberculosis variant microti]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A376WVB1

Antitoxin

Source ID Structure
AlphaFold DB A0A3T7EC32

References