Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4977809..4978640 Replicon chromosome
Accession NZ_CP093011
Organism Escherichia coli strain 131

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag LJF86_RS24345 Protein ID WP_000854814.1
Coordinates 4978266..4978640 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A641DSP2
Locus tag LJF86_RS24340 Protein ID WP_001546021.1
Coordinates 4977809..4978177 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF86_RS24305 (4972866) 4972866..4973936 + 1071 WP_000102631.1 patatin-like phospholipase family protein -
LJF86_RS24310 (4974072) 4974072..4974749 + 678 WP_001362823.1 hypothetical protein -
LJF86_RS24315 (4974765) 4974765..4975175 + 411 WP_000846704.1 hypothetical protein -
LJF86_RS24320 (4975396) 4975396..4976217 + 822 WP_001234710.1 DUF932 domain-containing protein -
LJF86_RS24325 (4976480) 4976480..4976953 + 474 WP_001385393.1 antirestriction protein -
LJF86_RS24330 (4976969) 4976969..4977445 + 477 WP_001186773.1 RadC family protein -
LJF86_RS24335 (4977508) 4977508..4977729 + 222 WP_000692323.1 DUF987 domain-containing protein -
LJF86_RS24340 (4977809) 4977809..4978177 + 369 WP_001546021.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
LJF86_RS24345 (4978266) 4978266..4978640 + 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
LJF86_RS24350 (4978637) 4978637..4978831 + 195 WP_000988601.1 DUF5983 family protein -
LJF86_RS24355 (4978877) 4978877..4978957 + 81 Protein_4792 hypothetical protein -
LJF86_RS24360 (4979469) 4979469..4979958 + 490 Protein_4793 IS3 family transposase -
LJF86_RS24365 (4979971) 4979971..4980513 - 543 Protein_4794 IS30-like element IS30 family transposase -
LJF86_RS24370 (4980510) 4980510..4980596 - 87 Protein_4795 hypothetical protein -
LJF86_RS24375 (4980578) 4980578..4980838 - 261 Protein_4796 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - sat 4976480..4984997 8517


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T237524 WP_000854814.1 NZ_CP093011:4978266-4978640 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T237524 NZ_LR882496:c2967635-2967312 [Mycobacterium tuberculosis variant microti]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCAGTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13607.47 Da        Isoelectric Point: 6.3139

>AT237524 WP_001546021.1 NZ_CP093011:4977809-4978177 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRASIRGLFSDADAYHPDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT237524 NZ_LR882496:c2967960-2967715 [Mycobacterium tuberculosis variant microti]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A641DSP2

References