Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 4693957..4694757 Replicon chromosome
Accession NZ_CP093011
Organism Escherichia coli strain 131

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag LJF86_RS22700 Protein ID WP_000342452.1
Coordinates 4694230..4694757 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag LJF86_RS22695 Protein ID WP_001277107.1
Coordinates 4693957..4694223 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF86_RS22675 (4689616) 4689616..4690284 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
LJF86_RS22680 (4690277) 4690277..4691335 + 1059 WP_001042003.1 permease-like cell division protein FtsX -
LJF86_RS22685 (4691580) 4691580..4692434 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
LJF86_RS22690 (4692705) 4692705..4693808 + 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
LJF86_RS22695 (4693957) 4693957..4694223 + 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
LJF86_RS22700 (4694230) 4694230..4694757 + 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
LJF86_RS22705 (4694754) 4694754..4695137 - 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
LJF86_RS22710 (4695669) 4695669..4696022 + 354 WP_001204533.1 head-tail joining protein -
LJF86_RS22715 (4696038) 4696038..4696571 + 534 WP_000974996.1 phage tail protein -
LJF86_RS22720 (4696568) 4696568..4696963 + 396 WP_000683079.1 phage minor tail U family protein -
LJF86_RS22725 (4696971) 4696971..4697720 + 750 WP_000235047.1 phage tail protein -
LJF86_RS22730 (4697739) 4697739..4698170 + 432 WP_001309426.1 phage minor tail protein G -
LJF86_RS22735 (4698197) 4698197..4698610 + 414 WP_094315422.1 phage tail assembly protein T -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T237522 WP_000342452.1 NZ_CP093011:4694230-4694757 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

>T237522 NZ_LR882496:c2862166-2861771 [Mycobacterium tuberculosis variant microti]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT237522 WP_001277107.1 NZ_CP093011:4693957-4694223 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp

>AT237522 NZ_LR882496:c2862408-2862163 [Mycobacterium tuberculosis variant microti]
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References