Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 4475895..4476454 Replicon chromosome
Accession NZ_CP093011
Organism Escherichia coli strain 131

Toxin (Protein)


Gene name relE Uniprot ID G4VUF8
Locus tag LJF86_RS21570 Protein ID WP_000421273.1
Coordinates 4476179..4476454 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SRR3
Locus tag LJF86_RS21565 Protein ID WP_001387467.1
Coordinates 4475895..4476179 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF86_RS21540 (4471280) 4471280..4471846 - 567 Protein_4232 zinc-binding dehydrogenase -
LJF86_RS21545 (4472199) 4472199..4473089 + 891 WP_001077068.1 dihydrodipicolinate synthase family protein -
LJF86_RS21550 (4473114) 4473114..4473494 + 381 WP_000710783.1 Rid family detoxifying hydrolase -
LJF86_RS21555 (4473527) 4473527..4474492 + 966 WP_001022265.1 2-keto-3-deoxygluconate transporter -
LJF86_RS21560 (4474538) 4474538..4475290 - 753 WP_001403368.1 IclR family transcriptional regulator -
LJF86_RS21565 (4475895) 4475895..4476179 + 285 WP_001387467.1 ribbon-helix-helix domain-containing protein Antitoxin
LJF86_RS21570 (4476179) 4476179..4476454 + 276 WP_000421273.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJF86_RS21575 (4476560) 4476560..4476763 + 204 Protein_4239 hypothetical protein -
LJF86_RS21580 (4476888) 4476888..4477016 - 129 Protein_4240 IS481 family transposase -
LJF86_RS21585 (4477049) 4477049..4478218 - 1170 WP_001403369.1 hypothetical protein -
LJF86_RS21590 (4478750) 4478750..4479018 + 269 Protein_4242 type II toxin-antitoxin system ParD family antitoxin -
LJF86_RS21595 (4479005) 4479005..4479295 + 291 Protein_4243 type II toxin-antitoxin system RelE/ParE family toxin -
LJF86_RS21600 (4479362) 4479362..4479544 + 183 WP_042344623.1 hypothetical protein -
LJF86_RS21605 (4479665) 4479665..4480405 + 741 WP_001066941.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4407369..4577081 169712


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10765.45 Da        Isoelectric Point: 9.9324

>T237512 WP_000421273.1 NZ_CP093011:4476179-4476454 [Escherichia coli]
MELKWTSKALSDLSRLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYEINGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T237512 NZ_LR882496:c2225622-2225062 [Mycobacterium tuberculosis variant microti]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10460.87 Da        Isoelectric Point: 5.6558

>AT237512 WP_001387467.1 NZ_CP093011:4475895-4476179 [Escherichia coli]
MQMKNNAAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
SDSLSTDNPLPVPR

Download         Length: 285 bp

>AT237512 NZ_LR882496:c2225960-2225619 [Mycobacterium tuberculosis variant microti]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y6H1

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y880

References