237511

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 4428127..4428728 Replicon chromosome
Accession NZ_CP093011
Organism Escherichia coli strain 131

Toxin (Protein)


Gene name doc Uniprot ID U9YA20
Locus tag LJF86_RS21315 Protein ID WP_001216045.1
Coordinates 4428348..4428728 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag LJF86_RS21310 Protein ID WP_001190712.1
Coordinates 4428127..4428348 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF86_RS21250 (4423228) 4423228..4423416 + 189 WP_000797279.1 hypothetical protein -
LJF86_RS21255 (4423418) 4423418..4423596 + 179 Protein_4174 hypothetical protein -
LJF86_RS21260 (4423930) 4423930..4424064 + 135 Protein_4175 hypothetical protein -
LJF86_RS25750 (4424494) 4424494..4424787 + 294 WP_225385044.1 DUF551 domain-containing protein -
LJF86_RS21270 (4424784) 4424784..4425044 + 261 WP_000969524.1 hypothetical protein -
LJF86_RS21275 (4425044) 4425044..4425325 + 282 WP_000002126.1 ASCH domain-containing protein -
LJF86_RS21280 (4425349) 4425349..4425642 + 294 WP_039719968.1 hypothetical protein -
LJF86_RS21285 (4425649) 4425649..4426023 + 375 WP_000988651.1 hypothetical protein -
LJF86_RS21290 (4426005) 4426005..4426655 + 651 WP_001702237.1 hypothetical protein -
LJF86_RS21295 (4426907) 4426907..4427257 - 351 WP_000551789.1 hypothetical protein -
LJF86_RS21300 (4427290) 4427290..4427541 + 252 WP_001283837.1 DNA polymerase III subunit theta -
LJF86_RS21305 (4427665) 4427665..4428054 + 390 WP_000506724.1 S24 family peptidase -
LJF86_RS21310 (4428127) 4428127..4428348 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LJF86_RS21315 (4428348) 4428348..4428728 + 381 WP_001216045.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LJF86_RS21320 (4428733) 4428733..4428912 + 180 WP_001749393.1 hypothetical protein -
LJF86_RS21325 (4428940) 4428940..4429983 + 1044 WP_000648827.1 DUF968 domain-containing protein -
LJF86_RS21330 (4430072) 4430072..4430524 + 453 WP_001312282.1 late promoter-activating protein (Gp10) -
LJF86_RS21335 (4430611) 4430611..4431804 + 1194 WP_000219604.1 terminase -
LJF86_RS21340 (4431846) 4431846..4433288 + 1443 WP_224114847.1 terminase -
LJF86_RS25755 (4433372) 4433372..4433602 + 231 Protein_4192 ash family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4407369..4577081 169712


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13588.29 Da        Isoelectric Point: 5.1514

>T237511 WP_001216045.1 NZ_CP093011:4428348-4428728 [Escherichia coli]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

>T237511 NZ_LR882496:c2218155-2217736 [Mycobacterium tuberculosis variant microti]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT237511 WP_001190712.1 NZ_CP093011:4428127-4428348 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp

>AT237511 NZ_LR882496:c2218424-2218164 [Mycobacterium tuberculosis variant microti]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLP7

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References