Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 452426..452897 | Replicon | chromosome |
| Accession | NZ_CP093011 | ||
| Organism | Escherichia coli strain 131 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | LJF86_RS02185 | Protein ID | WP_001303511.1 |
| Coordinates | 452426..452704 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | LJF86_RS02190 | Protein ID | WP_001302048.1 |
| Coordinates | 452706..452897 (-) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJF86_RS02150 (447611) | 447611..447880 | - | 270 | WP_000003742.1 | excisionase | - |
| LJF86_RS02155 (447942) | 447942..450413 | - | 2472 | WP_032284123.1 | exonuclease | - |
| LJF86_RS02160 (450509) | 450509..450697 | - | 189 | WP_000199480.1 | DUF1482 family protein | - |
| LJF86_RS02165 (450694) | 450694..450882 | - | 189 | WP_000449172.1 | cell division inhibition protein DicB | - |
| LJF86_RS02170 (451449) | 451449..451643 | + | 195 | WP_001295058.1 | hypothetical protein | - |
| LJF86_RS02175 (451632) | 451632..451970 | - | 339 | WP_000394541.1 | hypothetical protein | - |
| LJF86_RS02180 (451982) | 451982..452134 | - | 153 | WP_000380313.1 | DUF1391 family protein | - |
| LJF86_RS02185 (452426) | 452426..452704 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LJF86_RS02190 (452706) | 452706..452897 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| LJF86_RS02195 (452918) | 452918..453289 | - | 372 | WP_001169687.1 | hypothetical protein | - |
| LJF86_RS02200 (453388) | 453388..453690 | + | 303 | WP_000172738.1 | transcriptional regulator | - |
| LJF86_RS02205 (453687) | 453687..454112 | + | 426 | WP_000693943.1 | toxin YdaT family protein | - |
| LJF86_RS02210 (454135) | 454135..455097 | + | 963 | WP_000095673.1 | helix-turn-helix domain-containing protein | - |
| LJF86_RS02215 (455138) | 455138..455560 | + | 423 | WP_021534702.1 | DUF977 family protein | - |
| LJF86_RS02220 (455557) | 455557..455811 | + | 255 | WP_000004322.1 | hypothetical protein | - |
| LJF86_RS02225 (455804) | 455804..456115 | + | 312 | WP_021534703.1 | hypothetical protein | - |
| LJF86_RS02230 (456244) | 456244..456426 | + | 183 | WP_001224665.1 | hypothetical protein | - |
| LJF86_RS02235 (456419) | 456419..456595 | + | 177 | WP_021534704.1 | hypothetical protein | - |
| LJF86_RS02240 (456592) | 456592..456951 | + | 360 | WP_001289986.1 | hypothetical protein | - |
| LJF86_RS02245 (456952) | 456952..457167 | + | 216 | WP_000510387.1 | hypothetical protein | - |
| LJF86_RS02250 (457169) | 457169..457387 | + | 219 | WP_001142588.1 | DUF4014 family protein | - |
| LJF86_RS02255 (457389) | 457389..457652 | + | 264 | WP_000224216.1 | hypothetical protein | - |
| LJF86_RS02260 (457663) | 457663..457830 | + | 168 | WP_000207997.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 446524..478637 | 32113 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T237489 WP_001303511.1 NZ_CP093011:c452704-452426 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T237489 NZ_LR882496:718340-718735 [Mycobacterium tuberculosis variant microti]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT237489 WP_001302048.1 NZ_CP093011:c452897-452706 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT237489 NZ_LR882496:718086-718340 [Mycobacterium tuberculosis variant microti]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|