Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-ArgA
Location 4834753..4835572 Replicon chromosome
Accession NZ_CP093010
Organism Klebsiella michiganensis strain K342

Toxin (Protein)


Gene name yjhX Uniprot ID J5WT09
Locus tag MMY94_RS23175 Protein ID WP_004110819.1
Coordinates 4835315..4835572 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID A0A2J5QA69
Locus tag MMY94_RS23170 Protein ID WP_032693191.1
Coordinates 4834753..4835304 (-) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMY94_RS23140 (MMY94_23140) 4830677..4831450 + 774 WP_088168442.1 Zygote formation protein zyg1 -
MMY94_RS23145 (MMY94_23145) 4831761..4832234 + 474 WP_032693194.1 hypothetical protein -
MMY94_RS23150 (MMY94_23150) 4832503..4832852 - 350 Protein_4553 type II toxin-antitoxin system VapC family toxin -
MMY94_RS23155 (MMY94_23155) 4832915..4833073 - 159 Protein_4554 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
MMY94_RS23160 (MMY94_23160) 4833107..4833853 - 747 WP_223226754.1 class I SAM-dependent methyltransferase -
MMY94_RS23165 (MMY94_23165) 4834277..4834639 - 363 Protein_4556 class I SAM-dependent methyltransferase -
MMY94_RS23170 (MMY94_23170) 4834753..4835304 - 552 WP_032693191.1 N-acetyltransferase Antitoxin
MMY94_RS23175 (MMY94_23175) 4835315..4835572 - 258 WP_004110819.1 YjhX family toxin Toxin
MMY94_RS23180 (MMY94_23180) 4836248..4837432 + 1185 WP_014228054.1 mannonate dehydratase -
MMY94_RS23185 (MMY94_23185) 4837506..4838981 + 1476 WP_014228053.1 fructuronate reductase -
MMY94_RS23190 (MMY94_23190) 4839120..4839896 + 777 WP_004847986.1 Uxu operon transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9552.07 Da        Isoelectric Point: 11.1381

>T237487 WP_004110819.1 NZ_CP093010:c4835572-4835315 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

>T237487 NZ_LR882496:705161-705562 [Mycobacterium tuberculosis variant microti]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 20154.00 Da        Isoelectric Point: 6.4903

>AT237487 WP_032693191.1 NZ_CP093010:c4835304-4834753 [Klebsiella michiganensis]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGVGVGGELIRHGIEQLKAMGSQMVFVLGHAAYYPRHGFEPCAGDKGYPAPYPIPEAHKACWMLQRLSS
QPLGRTGQIQCARALMKPEHWRE

Download         Length: 552 bp

>AT237487 NZ_LR882496:704919-705164 [Mycobacterium tuberculosis variant microti]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H6Y2

Antitoxin

Source ID Structure
AlphaFold DB A0A2J5QA69

References