Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 348682..349288 Replicon chromosome
Accession NC_012588
Organism Sulfolobus islandicus M.14.25

Toxin (Protein)


Gene name vapC Uniprot ID M9U4G3
Locus tag M1425_RS01980 Protein ID WP_012710548.1
Coordinates 348682..349044 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C3MUN8
Locus tag M1425_RS01985 Protein ID WP_012710549.1
Coordinates 349067..349288 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1425_RS01965 (M1425_0396) 344498..345895 - 1398 WP_012710545.1 glycosyltransferase -
M1425_RS01970 (M1425_0397) 345940..346533 - 594 WP_012710546.1 hypothetical protein -
M1425_RS01975 (M1425_0398) 346625..348178 + 1554 WP_012710547.1 aldehyde dehydrogenase family protein -
M1425_RS15020 348230..348400 - 171 WP_175282303.1 hypothetical protein -
M1425_RS01980 (M1425_0399) 348682..349044 - 363 WP_012710548.1 type II toxin-antitoxin system VapC family toxin Toxin
M1425_RS01985 (M1425_0400) 349067..349288 - 222 WP_012710549.1 hypothetical protein Antitoxin
M1425_RS01995 (M1425_0402) 350569..351102 - 534 WP_012710551.1 ADP-ribose-binding protein -
M1425_RS02000 (M1425_0403) 351257..352402 + 1146 WP_012710552.1 glycosyltransferase -
M1425_RS02005 (M1425_0404) 352407..352967 + 561 WP_012710553.1 PIG-L deacetylase family protein -
M1425_RS02010 (M1425_0405) 352971..353408 + 438 WP_012710554.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(21-113)

Antitoxin

Putative antitoxin VapB3-like

(1-73)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13870.21 Da        Isoelectric Point: 9.2430

>T23748 WP_012710548.1 NC_012588:c349044-348682 [Sulfolobus islandicus M.14.25]
VTKEKGWNRITELLKDSETLDLALVEVSNVIWKKVVLTNEITPQDANKAIMIIKEYLPQLLTVNKSVKLLERAIDISIRE
KLTIYDSLYIALAESKRSKLLTSDKKQYEVARKYVDSELF

Download         Length: 363 bp

>T23748 NC_012588:c349044-348682 [Sulfolobus islandicus M.14.25]
GTGACTAAGGAGAAGGGATGGAATAGAATTACGGAGTTACTAAAGGATAGTGAAACTCTAGATCTGGCGCTAGTAGAAGT
TTCCAATGTTATTTGGAAGAAAGTGGTGTTAACAAACGAGATTACTCCACAGGATGCCAATAAGGCGATTATGATTATTA
AGGAATATCTACCTCAATTGCTGACTGTAAATAAAAGCGTTAAACTCTTGGAAAGAGCTATAGATATCTCTATAAGGGAA
AAACTGACTATATACGACTCGCTATATATTGCCTTAGCGGAAAGCAAGAGAAGTAAATTATTAACCAGCGATAAAAAGCA
ATATGAGGTTGCAAGAAAATACGTGGACTCGGAATTATTTTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8922.19 Da        Isoelectric Point: 4.6475

>AT23748 WP_012710549.1 NC_012588:c349288-349067 [Sulfolobus islandicus M.14.25]
MKMVYSLRIDKELREEMEKYDIKWNEEIEGFIRKRLEELKKEEILKRINEILSTMPETNSSGAEMVREDRDNN

Download         Length: 222 bp

>AT23748 NC_012588:c349288-349067 [Sulfolobus islandicus M.14.25]
ATGAAAATGGTATACAGTTTAAGGATAGATAAAGAATTACGTGAGGAGATGGAAAAGTACGACATAAAGTGGAATGAAGA
GATAGAGGGTTTCATAAGGAAAAGGCTTGAGGAATTGAAAAAAGAGGAGATTCTAAAGAGGATTAATGAGATCCTTTCAA
CCATGCCGGAAACTAATTCAAGTGGTGCGGAAATGGTGAGGGAAGATAGGGATAATAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M9U4G3

Antitoxin

Source ID Structure
AlphaFold DB C3MUN8

References