Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 814874..815652 Replicon chromosome
Accession NZ_CP093010
Organism Klebsiella michiganensis strain K342

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1D8JZH2
Locus tag MMY94_RS03975 Protein ID WP_032692863.1
Coordinates 815164..815652 (+) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A1D8JZH7
Locus tag MMY94_RS03970 Protein ID WP_032692864.1
Coordinates 814874..815167 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMY94_RS03950 (MMY94_03950) 810035..811180 - 1146 WP_004854188.1 PLP-dependent aspartate aminotransferase family protein -
MMY94_RS03955 (MMY94_03955) 811191..812561 - 1371 WP_025105933.1 cystathionine beta-synthase -
MMY94_RS03960 (MMY94_03960) 812735..812911 + 177 WP_177341169.1 hypothetical protein -
MMY94_RS03965 (MMY94_03965) 813107..814495 + 1389 WP_032692865.1 DASS family sodium-coupled anion symporter -
MMY94_RS03970 (MMY94_03970) 814874..815167 + 294 WP_032692864.1 DUF1778 domain-containing protein Antitoxin
MMY94_RS03975 (MMY94_03975) 815164..815652 + 489 WP_032692863.1 GNAT family N-acetyltransferase Toxin
MMY94_RS03980 (MMY94_03980) 815717..816415 + 699 WP_032692862.1 hypothetical protein -
MMY94_RS03985 (MMY94_03985) 816522..817868 - 1347 WP_241463461.1 hypothetical protein -
MMY94_RS03990 (MMY94_03990) 818024..818221 - 198 WP_241463462.1 hypothetical protein -
MMY94_RS03995 (MMY94_03995) 818218..820128 - 1911 WP_241463463.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-143)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17694.67 Da        Isoelectric Point: 8.1567

>T237475 WP_032692863.1 NZ_CP093010:815164-815652 [Klebsiella michiganensis]
MISTPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQLSGASRTFVCCHDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDRSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSNEAREFYLRVGFEPSLIDPMMLMVTLGDLVE
SI

Download         Length: 489 bp

>T237475 NZ_LR882494:c41799-41617 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
AGCCGCCATTGAACTGGACGAACGGATTGGTTGTTCAGCCAGCCTCCTGTTCTCCCTTTCTTTTATCAGTGTACAGGTGC
ATGACAACATAATCACGGTATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10930.56 Da        Isoelectric Point: 9.9171

>AT237475 WP_032692864.1 NZ_CP093010:814874-815167 [Klebsiella michiganensis]
MPAANSMAMKRETLNLRIRPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT237475 NZ_LR882494:c41993-41796 [Escherichia coli]
ATGGACCGTAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGA
CCAGGTTGAGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCAT
GGCGGGATGAAATGAGCAGGAAAGTCGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D8JZH2

Antitoxin

Source ID Structure
AlphaFold DB A0A1D8JZH7

References