Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicA
Location 406012..406417 Replicon chromosome
Accession NZ_CP092983
Organism Leptospira interrogans strain FMAS_KG2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FH588_RS01680 Protein ID WP_061257196.1
Coordinates 406232..406417 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FH588_RS01675 Protein ID WP_235593300.1
Coordinates 406012..406215 (-) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FH588_RS01675 (FH588_01675) 406012..406215 - 204 WP_235593300.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FH588_RS01680 (FH588_01680) 406232..406417 - 186 WP_061257196.1 type II toxin-antitoxin system HicA family toxin Toxin
FH588_RS01685 (FH588_01685) 406683..406949 - 267 WP_061256493.1 hypothetical protein -
FH588_RS01690 (FH588_01690) 406946..408139 - 1194 WP_241468464.1 chromosome partitioning protein ParB -
FH588_RS01695 (FH588_01695) 408136..408909 - 774 WP_241468465.1 ParA family protein -
FH588_RS01700 (FH588_01700) 409073..410164 - 1092 WP_240303569.1 tyrosine-type recombinase/integrase -
FH588_RS01705 (FH588_01705) 410161..410541 - 381 WP_017860342.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-62)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6836.98 Da        Isoelectric Point: 10.6223

>T237467 WP_061257196.1 NZ_CP092983:c406417-406232 [Leptospira interrogans]
MKVKEIIKILEDDGWYLVDQRGSHRQFKHTLKSGRVTVAGKSSMDLPPGTLNSILKQSGLK

Download         Length: 186 bp

>T237467 NZ_LR882493:c2234782-2233460 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTTAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCTGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCGTTTTTGATGGGGTCCAGCGAGGCGCTTCGCGATCGTTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7380.55 Da        Isoelectric Point: 4.5125

>AT237467 WP_235593300.1 NZ_CP092983:c406215-406012 [Leptospira interrogans]
MEYPVMIEKNSTGYGAYVPDLPGCVAVGETEAEVTRLIKEAIEFHLEGMRKDGERVPNPSKVMLIAV

Download         Length: 204 bp

>AT237467 NZ_LR882493:c2235048-2234782 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References