Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicA
Location 385901..386306 Replicon chromosome
Accession NZ_CP092983
Organism Leptospira interrogans strain FMAS_KG2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FH588_RS01580 Protein ID WP_061257196.1
Coordinates 386121..386306 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FH588_RS01575 Protein ID WP_235593300.1
Coordinates 385901..386104 (-) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FH588_RS01575 (FH588_01575) 385901..386104 - 204 WP_235593300.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FH588_RS01580 (FH588_01580) 386121..386306 - 186 WP_061257196.1 type II toxin-antitoxin system HicA family toxin Toxin
FH588_RS01585 (FH588_01585) 386572..386838 - 267 WP_061256493.1 hypothetical protein -
FH588_RS01590 (FH588_01590) 386835..388028 - 1194 WP_241468464.1 chromosome partitioning protein ParB -
FH588_RS01595 (FH588_01595) 388025..388798 - 774 WP_241468465.1 ParA family protein -
FH588_RS01600 (FH588_01600) 388962..390053 - 1092 WP_240303569.1 tyrosine-type recombinase/integrase -
FH588_RS01605 (FH588_01605) 390050..390430 - 381 WP_017860342.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-62)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6836.98 Da        Isoelectric Point: 10.6223

>T237466 WP_061257196.1 NZ_CP092983:c386306-386121 [Leptospira interrogans]
MKVKEIIKILEDDGWYLVDQRGSHRQFKHTLKSGRVTVAGKSSMDLPPGTLNSILKQSGLK

Download         Length: 186 bp

>T237466 NZ_LR882493:c1928644-1928537 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7380.55 Da        Isoelectric Point: 4.5125

>AT237466 WP_235593300.1 NZ_CP092983:c386104-385901 [Leptospira interrogans]
MEYPVMIEKNSTGYGAYVPDLPGCVAVGETEAEVTRLIKEAIEFHLEGMRKDGERVPNPSKVMLIAV

Download         Length: 204 bp

>AT237466 NZ_LR882493:1928691-1928757 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References