Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 52550..53121 Replicon plasmid unnamed
Accession NZ_CP092982
Organism Mycobacterium marinum strain H01

Toxin (Protein)


Gene name doc Uniprot ID A0A2Z5YP41
Locus tag MML61_RS27290 Protein ID WP_038582272.1
Coordinates 52550..52927 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag MML61_RS27295 Protein ID WP_038582269.1
Coordinates 52924..53121 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MML61_RS27265 (MML61_27465) 48298..48603 - 306 WP_157761246.1 type VII secretion target -
MML61_RS27270 (MML61_27470) 48678..48983 - 306 WP_142399673.1 hypothetical protein -
MML61_RS27275 (MML61_27475) 49008..50474 - 1467 WP_050674712.1 DUF4226 domain-containing protein -
MML61_RS27280 (MML61_27480) 50751..51653 - 903 WP_157761245.1 DUF2637 domain-containing protein -
MML61_RS27285 (MML61_27485) 51748..51888 - 141 WP_157761244.1 hypothetical protein -
MML61_RS27290 (MML61_27490) 52550..52927 - 378 WP_038582272.1 Fic family protein Toxin
MML61_RS27295 (MML61_27495) 52924..53121 - 198 WP_038582269.1 hypothetical protein Antitoxin
MML61_RS27300 (MML61_27500) 53760..55406 + 1647 WP_038582264.1 ParB N-terminal domain-containing protein -
MML61_RS27305 (MML61_27505) 56119..56352 + 234 WP_038582261.1 glutaredoxin-like protein NrdH -
MML61_RS27310 (MML61_27510) 56416..56586 + 171 WP_157761243.1 hypothetical protein -
MML61_RS27315 (MML61_27515) 56608..57315 + 708 WP_050674710.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - eccA5 / esxN 1..115362 115362


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(28-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13370.18 Da        Isoelectric Point: 4.2208

>T237465 WP_038582272.1 NZ_CP092982:c52927-52550 [Mycobacterium marinum]
VTEYPTVDDVLIVAEYACGFRPLVSDPGLFESSLMRPAATVFGSDAYPTVWDKAAALLHSFVTTQSLADGNKRTGWAACW
LLLGLNGHRLSAALDVDAAEKFVLAIAGGELAWEQIAARLPDFAD

Download         Length: 378 bp

>T237465 NZ_LR882493:c1928108-1928001 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 6950.87 Da        Isoelectric Point: 9.0010

>AT237465 WP_038582269.1 NZ_CP092982:c53121-52924 [Mycobacterium marinum]
MPALNVDFSDEELAIVRSAASNAGASMRGFAKQAILDKAVDRAGRVHALGREIADRSAELNRRLA

Download         Length: 198 bp

>AT237465 NZ_LR882493:1928161-1928222 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z5YP41

Antitoxin

Source ID Structure

References