Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 5394308..5394947 Replicon chromosome
Accession NZ_CP092981
Organism Mycobacterium marinum strain H01

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID A0A2Z5YL42
Locus tag MML61_RS22495 Protein ID WP_020729617.1
Coordinates 5394308..5394754 (-) Length 149 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID B2HEJ8
Locus tag MML61_RS22500 Protein ID WP_011738542.1
Coordinates 5394759..5394947 (-) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MML61_RS22470 (MML61_22630) 5389483..5391003 + 1521 WP_020729620.1 carotenoid oxygenase family protein -
MML61_RS22475 (MML61_22635) 5391020..5391493 + 474 WP_012396158.1 VOC family protein -
MML61_RS22480 (MML61_22640) 5391499..5391933 - 435 WP_012396159.1 hypothetical protein -
MML61_RS22485 (MML61_22645) 5392004..5392777 - 774 WP_273590475.1 VOC family protein -
MML61_RS22490 (MML61_22650) 5393198..5394196 + 999 WP_231389724.1 EspA/EspE family type VII secretion system effector -
MML61_RS22495 (MML61_22655) 5394308..5394754 - 447 WP_020729617.1 SRPBCC family protein Toxin
MML61_RS22500 (MML61_22660) 5394759..5394947 - 189 WP_011738542.1 antitoxin Antitoxin
MML61_RS22505 (MML61_22665) 5395049..5396254 - 1206 WP_273590476.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 149 a.a.        Molecular weight: 15851.39 Da        Isoelectric Point: 8.6574

>T237464 WP_020729617.1 NZ_CP092981:c5394754-5394308 [Mycobacterium marinum]
MAKLSGSIDVPLSPDEAWMHASDLSRFKEWLTIHRVWRSTLPETLEKGAVVESIVQVKGMHNRIKWTIVRYQPPEGMTLN
GDGVGGVKVKLMAKVAAGEEGSVVSFDVHLGGPALFGPIGMVVAAALRTDINASLRNFVTVFAPSAAG

Download         Length: 447 bp

>T237464 NZ_LR882493:1291615-1292013 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6586.35 Da        Isoelectric Point: 4.7205

>AT237464 WP_011738542.1 NZ_CP092981:c5394947-5394759 [Mycobacterium marinum]
MGILDKAKDLLAQNADKVETVIDKAGEFVDEKTEGKYSDTIHKVQEGAKKVAGPGAAGEQQN

Download         Length: 189 bp

>AT237464 NZ_LR882493:1291388-1291615 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z5YL42

Antitoxin

Source ID Structure
AlphaFold DB A0A7I7LB02

References