237463

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 3461093..3461628 Replicon chromosome
Accession NZ_CP092981
Organism Mycobacterium marinum strain H01

Toxin (Protein)


Gene name mazF Uniprot ID A0A2Z5YH00
Locus tag MML61_RS14615 Protein ID WP_036455701.1
Coordinates 3461296..3461628 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A7I7LGS6
Locus tag MML61_RS14610 Protein ID WP_036455700.1
Coordinates 3461093..3461299 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MML61_RS14590 (MML61_14725) 3456420..3457229 + 810 WP_231389684.1 ParA family protein -
MML61_RS14595 (MML61_14730) 3457322..3458149 - 828 WP_020729183.1 DUF1906 domain-containing protein -
MML61_RS14600 (MML61_14735) 3458477..3460162 - 1686 WP_273590233.1 GMC family oxidoreductase N-terminal domain-containing protein -
MML61_RS14605 (MML61_14740) 3460410..3460760 - 351 WP_020729185.1 cupin domain-containing protein -
MML61_RS14610 (MML61_14745) 3461093..3461299 + 207 WP_036455700.1 DUF3018 family protein Antitoxin
MML61_RS14615 (MML61_14750) 3461296..3461628 + 333 WP_036455701.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MML61_RS14620 (MML61_14755) 3462452..3462568 + 117 WP_231382648.1 DUF2384 domain-containing protein -
MML61_RS14625 (MML61_14760) 3462569..3463123 + 555 WP_020729188.1 RES domain-containing protein -
MML61_RS14630 (MML61_14765) 3463402..3463635 + 234 WP_020729189.1 hypothetical protein -
MML61_RS14635 (MML61_14770) 3463625..3463936 + 312 WP_020729190.1 type II toxin-antitoxin system PemK/MazF family toxin -
MML61_RS14640 (MML61_14775) 3464329..3464526 + 198 Protein_2907 hypothetical protein -
MML61_RS14645 (MML61_14780) 3464630..3466033 + 1404 WP_243703224.1 adenylate/guanylate cyclase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-105)

Antitoxin

Antitoxin MazE-like

(4-66)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11841.67 Da        Isoelectric Point: 7.3196

>T237463 WP_036455701.1 NZ_CP092981:3461296-3461628 [Mycobacterium marinum]
VNRGEIWTVAGGVYATKPHPAVIVQDDLFDATSSVTVAPMSSTLLDAPLMRIRIAGGDGRLSGLDHNSDVMIDKLTTVKR
SNVHARVGRLTAEQVVEVERVMMAFLGLAR

Download         Length: 333 bp

>T237463 NZ_LR882493:1066959-1067270 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7999.86 Da        Isoelectric Point: 4.8359

>AT237463 WP_036455700.1 NZ_CP092981:3461093-3461299 [Mycobacterium marinum]
MAVRDRVGEYRRRMRERGLRPLQVWVPDVRTESFAAEAHRQASLVARADERGDDQDFIEAISTPWDEE

Download         Length: 207 bp

>AT237463 NZ_LR882493:1067267-1067686 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAGTATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCGGTT
GGCGTGGCGTTACTTCGCACGTTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z5YH00

Antitoxin

Source ID Structure
AlphaFold DB A0A7I7LGS6

References