Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2433236..2433874 Replicon chromosome
Accession NZ_CP092973
Organism Escherichia coli strain WCHEC005215

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag MM176_RS11655 Protein ID WP_001447010.1
Coordinates 2433698..2433874 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MM176_RS11650 Protein ID WP_001270286.1
Coordinates 2433236..2433652 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MM176_RS11630 (2428388) 2428388..2429329 - 942 WP_001251304.1 ABC transporter permease -
MM176_RS11635 (2429330) 2429330..2430343 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
MM176_RS11640 (2430361) 2430361..2431506 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
MM176_RS11645 (2431751) 2431751..2433157 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
MM176_RS11650 (2433236) 2433236..2433652 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
MM176_RS11655 (2433698) 2433698..2433874 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
MM176_RS11660 (2434096) 2434096..2434326 + 231 WP_000494244.1 YncJ family protein -
MM176_RS11665 (2434418) 2434418..2436379 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
MM176_RS11670 (2436452) 2436452..2436988 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
MM176_RS11675 (2437080) 2437080..2438255 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T237453 WP_001447010.1 NZ_CP092973:c2433874-2433698 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T237453 NZ_LR882058:50832-50984 [Escherichia coli]
ATGCCACAGCGAACATTTTTAATGATGTTGATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGGCTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT237453 WP_001270286.1 NZ_CP092973:c2433652-2433236 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT237453 NZ_LR882058:c50782-50720 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References