Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1007306..1007964 Replicon plasmid pNGR234b
Accession NC_012586
Organism Sinorhizobium fredii NGR234

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NGR_RS04960 Protein ID WP_015887143.1
Coordinates 1007306..1007707 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NGR_RS04965 Protein ID WP_015887144.1
Coordinates 1007704..1007964 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGR_RS04935 1002491..1003681 - 1191 WP_015887138.1 DUF1173 domain-containing protein -
NGR_RS04940 1003976..1004167 + 192 WP_164923884.1 hypothetical protein -
NGR_RS04945 1004182..1005219 + 1038 WP_015887140.1 toprim domain-containing protein -
NGR_RS04950 1005540..1006481 + 942 WP_015887141.1 DUF2493 domain-containing protein -
NGR_RS04955 1006577..1007206 + 630 WP_164924077.1 plasmid pRiA4b ORF-3 family protein -
NGR_RS04960 1007306..1007707 - 402 WP_015887143.1 type II toxin-antitoxin system VapC family toxin Toxin
NGR_RS04965 1007704..1007964 - 261 WP_015887144.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NGR_RS04970 1008307..1008567 + 261 WP_164923885.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
NGR_RS04975 1008930..1009196 + 267 WP_015633558.1 hypothetical protein -
NGR_RS04980 1009193..1009591 + 399 WP_015887146.1 type II toxin-antitoxin system VapC family toxin -
NGR_RS04985 1010205..1010528 + 324 WP_015887148.1 DUF736 family protein -
NGR_RS32240 1011018..1011158 + 141 WP_165447119.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB / katA 1..2430033 2430033


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin

SpoVT-AbrB domain

(8-43)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14360.40 Da        Isoelectric Point: 4.8053

>T23745 WP_015887143.1 NC_012586:c1007707-1007306 [Sinorhizobium fredii NGR234]
VISHLLDTNAVIALIGRSDRLVSRVLDSPQGSIGLPSVVAYELYFGGQKSAKVQHNLETLRLLMADFPILDFDQNDAFVA
GEIRAALAAKGTPIGPYDVLIAGQAKARGLTLVTNNVGEFNRVENLQVEDWSL

Download         Length: 402 bp

>T23745 NC_012586:c1007707-1007306 [Sinorhizobium fredii NGR234]
GTGATCTCGCATCTTCTCGACACCAACGCCGTCATTGCCTTGATCGGCCGCTCGGATAGATTGGTCAGCCGGGTACTCGA
TAGCCCTCAGGGCAGTATCGGCCTGCCGTCGGTCGTCGCCTATGAACTCTATTTCGGAGGGCAGAAAAGCGCGAAGGTCC
AACACAACCTCGAAACCTTGCGTTTGTTGATGGCGGATTTTCCGATCCTCGACTTTGACCAGAACGATGCCTTTGTCGCG
GGCGAAATCCGGGCTGCTCTTGCCGCGAAGGGGACGCCCATCGGCCCCTATGACGTGCTGATCGCAGGGCAGGCGAAAGC
CCGTGGCTTGACCCTCGTCACCAACAATGTCGGCGAGTTCAACAGGGTTGAGAACCTGCAGGTGGAGGATTGGTCGCTGT
GA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9760.90 Da        Isoelectric Point: 4.6510

>AT23745 WP_015887144.1 NC_012586:c1007964-1007704 [Sinorhizobium fredii NGR234]
MPHLARVFQSGNSQAVRLPKEFRFNVERVEITQEGDALILRPHVEAGEPWSSLKAALARGMSDDFIESGREQPEQQDRPE
LDAVFQ

Download         Length: 261 bp

>AT23745 NC_012586:c1007964-1007704 [Sinorhizobium fredii NGR234]
ATGCCCCATCTTGCACGGGTATTCCAGTCCGGAAACTCGCAGGCCGTCCGCCTGCCGAAAGAATTCCGCTTCAACGTCGA
GCGCGTGGAGATCACGCAGGAGGGCGATGCTCTCATTCTCCGCCCGCATGTCGAGGCGGGCGAGCCGTGGTCGTCGCTGA
AAGCAGCGCTGGCCCGGGGCATGAGTGACGACTTCATCGAGAGCGGGCGCGAGCAGCCGGAACAGCAGGATCGACCGGAG
CTTGACGCGGTGTTTCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References