237443

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1872179..1873014 Replicon chromosome
Accession NZ_CP092973
Organism Escherichia coli strain WCHEC005215

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1X9TM58
Locus tag MM176_RS08885 Protein ID WP_000854761.1
Coordinates 1872179..1872556 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag MM176_RS08890 Protein ID WP_001295723.1
Coordinates 1872646..1873014 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MM176_RS08845 (1867568) 1867568..1867834 - 267 WP_087757644.1 EutP/PduV family microcompartment system protein -
MM176_RS08850 (1868204) 1868204..1868593 - 390 WP_001445118.1 IS110 family transposase -
MM176_RS08855 (1868782) 1868782..1869006 - 225 Protein_1745 transposase -
MM176_RS08860 (1869087) 1869087..1869491 + 405 WP_000839179.1 transposase -
MM176_RS08865 (1869488) 1869488..1869835 + 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -
MM176_RS08870 (1869884) 1869884..1871423 + 1540 Protein_1748 IS66-like element ISEc22 family transposase -
MM176_RS08875 (1871854) 1871854..1871934 - 81 Protein_1749 hypothetical protein -
MM176_RS08880 (1872034) 1872034..1872182 - 149 Protein_1750 DUF5983 family protein -
MM176_RS08885 (1872179) 1872179..1872556 - 378 WP_000854761.1 TA system toxin CbtA family protein Toxin
MM176_RS08890 (1872646) 1872646..1873014 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MM176_RS08895 (1873177) 1873177..1873398 - 222 WP_000692345.1 DUF987 domain-containing protein -
MM176_RS08900 (1873461) 1873461..1873937 - 477 WP_001186774.1 RadC family protein -
MM176_RS08905 (1873953) 1873953..1874426 - 474 WP_000855059.1 antirestriction protein -
MM176_RS08910 (1874768) 1874768..1875586 - 819 WP_001234729.1 DUF932 domain-containing protein -
MM176_RS08915 (1875704) 1875704..1875899 - 196 Protein_1757 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14205.25 Da        Isoelectric Point: 7.3249

>T237443 WP_000854761.1 NZ_CP092973:c1872556-1872179 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T237443 NZ_LR882057:2812570-2812677 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT237443 WP_001295723.1 NZ_CP092973:c1873014-1872646 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT237443 NZ_LR882057:c2812520-2812457 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X9TM58

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References