Detailed information of TA system TA237431

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 1763387..1764645
• Replicon: chromosome
• Accession: NZ_CP092972
• Organism: Pseudomonas aeruginosa strain PA01135

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9I4U4
• Locus tag: MMG97_RS08370
• Protein ID: WP_003112528.1
• Coordinates: 1763890..1764645 (+)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: MMG97_RS08365
• Protein ID: WP_003086329.1
• Coordinates: 1763387..1763755 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMG97_RS08345 (MMG97_08340)	1759550..1759825	+	276	WP_010793902.1	zinc ribbon domain-containing protein	-
MMG97_RS08350 (MMG97_08345)	1759828..1760304	-	477	WP_003112531.1	hypothetical protein	-
MMG97_RS08355 (MMG97_08350)	1760383..1761972	+	1590	WP_010895535.1	aldehyde dehydrogenase family protein	-
MMG97_RS08360 (MMG97_08355)	1762028..1763314	+	1287	WP_003112529.1	FAD-binding oxidoreductase	-
MMG97_RS08365 (MMG97_08360)	1763387..1763755	+	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
MMG97_RS08370 (MMG97_08365)	1763890..1764645	+	756	WP_003112528.1	RES family NAD+ phosphorylase	Toxin
MMG97_RS08375 (MMG97_08370)	1765413..1766774	+	1362	WP_010895536.1	DNA recombination protein RmuC	-
MMG97_RS08380 (MMG97_08375)	1766929..1769472	-	2544	WP_003112526.1	acyl-homoserine-lactone acylase QuiP	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28278.42 Da
• Isoelectric Point: 7.7294

>T237431 WP_003112528.1 NZ_CP092972:1763890-1764645 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T237431 NZ_LR882057:264313-264588 [Escherichia coli]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT237431 WP_003086329.1 NZ_CP092972:1763387-1763755 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT237431 NZ_LR882057:264585-264944 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCTAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Structures

Toxin

• AlphaFold DB: Q9I4U4

Antitoxin

• AlphaFold DB: V6AJU7