Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 143573..144078 Replicon chromosome
Accession NZ_CP092972
Organism Pseudomonas aeruginosa strain PA01135

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag MMG97_RS00660 Protein ID WP_003083773.1
Coordinates 143573..143854 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag MMG97_RS00665 Protein ID WP_003112628.1
Coordinates 143851..144078 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMG97_RS00635 (MMG97_00635) 138824..140173 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
MMG97_RS00640 (MMG97_00640) 140222..140908 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
MMG97_RS00645 (MMG97_00645) 141009..141743 + 735 WP_003115036.1 GntR family transcriptional regulator -
MMG97_RS00650 (MMG97_00650) 141923..142333 + 411 WP_003101225.1 aegerolysin family protein -
MMG97_RS00655 (MMG97_00655) 142365..143273 - 909 WP_003083769.1 LysR family transcriptional regulator -
MMG97_RS00660 (MMG97_00660) 143573..143854 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
MMG97_RS00665 (MMG97_00665) 143851..144078 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
MMG97_RS00670 (MMG97_00670) 144254..144874 - 621 WP_003101226.1 hypothetical protein -
MMG97_RS00675 (MMG97_00675) 144975..145475 + 501 WP_003112629.1 LEA type 2 family protein -
MMG97_RS00680 (MMG97_00680) 145548..145889 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
MMG97_RS00685 (MMG97_00685) 145971..147398 - 1428 WP_003083784.1 GABA permease -
MMG97_RS00690 (MMG97_00690) 147567..149060 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T237429 WP_003083773.1 NZ_CP092972:c143854-143573 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T237429 NZ_LR882055:35493-35651 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT237429 WP_003112628.1 NZ_CP092972:c144078-143851 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT237429 NZ_LR882055:35382-35447 [Escherichia coli]
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References