Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 3822074..3822852 Replicon chromosome
Accession NZ_CP092968
Organism Methylocystis parvus OBBP

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag MMG94_RS18515 Protein ID WP_244415240.1
Coordinates 3822406..3822852 (+) Length 149 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag MMG94_RS18510 Protein ID WP_020372412.1
Coordinates 3822074..3822367 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMG94_RS18495 (MMG94_18420) 3818344..3819561 + 1218 WP_016918877.1 glycolate oxidase subunit GlcE -
MMG94_RS18500 (MMG94_18425) 3819561..3820865 + 1305 WP_016918878.1 glycolate oxidase subunit GlcF -
MMG94_RS18505 (MMG94_18430) 3820917..3821951 - 1035 WP_016918879.1 tryptophan--tRNA ligase -
MMG94_RS18510 (MMG94_18435) 3822074..3822367 + 294 WP_020372412.1 DUF1778 domain-containing protein Antitoxin
MMG94_RS18515 (MMG94_18440) 3822406..3822852 + 447 WP_244415240.1 GNAT family N-acetyltransferase Toxin
MMG94_RS18520 (MMG94_18445) 3822842..3824143 - 1302 WP_016918882.1 ATP-dependent protease ATPase subunit HslU -
MMG94_RS18525 (MMG94_18450) 3824144..3824707 - 564 WP_016918883.1 ATP-dependent protease subunit HslV -
MMG94_RS18530 (MMG94_18455) 3825086..3827713 + 2628 WP_016918884.1 ATP-dependent chaperone ClpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(29-131)

Antitoxin

Vibrio phage ICP1, Orf50

(13-96)


Sequences

Toxin        


Download         Length: 149 a.a.        Molecular weight: 16333.99 Da        Isoelectric Point: 10.7001

>T237425 WP_244415240.1 NZ_CP092968:3822406-3822852 [Methylocystis parvus OBBP]
IAESFDCGVAVLNDWLRRRAMPNQLTGASRTFVISRDERVVGYYALAAGAIASHEAPSRLSRNMPDPIPVFILGRLAVDR
SEQGRMLGSLLLRDAIIRTRAAAEFGGIAGLLVHALSVEAKRFYMHRGFVESPSRPMTLLARLKDIKE

Download         Length: 447 bp

>T237425 NZ_LR882053:c5488-5213 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGTCGCGGTTATTTGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAAATTAATGGCCAGACTATTTAT
GTATTGCGTCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10766.34 Da        Isoelectric Point: 10.4718

>AT237425 WP_020372412.1 NZ_CP092968:3822074-3822367 [Methylocystis parvus OBBP]
MAQATKRNELSGRGLVNVRMAAEDRNIIDQAARIAGKSRTEFMVEAARRAAQDTVLDANLIVVDGKTFEQFRAIFDAPAK
PNAHIQKLMNLKAPWES

Download         Length: 294 bp

>AT237425 NZ_LR882053:c5772-5488 [Escherichia coli]
ATGCAAATGAAAAACAATGCCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGTTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
TCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References