Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relE/YoeB-YefM
Location 1217507..1218012 Replicon chromosome
Accession NZ_CP092968
Organism Methylocystis parvus OBBP

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6B8M7C1
Locus tag MMG94_RS06050 Protein ID WP_016918191.1
Coordinates 1217507..1217761 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relE Uniprot ID A0A6B8M0R4
Locus tag MMG94_RS06055 Protein ID WP_016918192.1
Coordinates 1217758..1218012 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMG94_RS06020 (MMG94_06005) 1213533..1213802 - 270 WP_040578824.1 hypothetical protein -
MMG94_RS06025 (MMG94_06010) 1214008..1214340 - 333 WP_154419989.1 hypothetical protein -
MMG94_RS06030 (MMG94_06015) 1214498..1214962 + 465 WP_040578826.1 redoxin domain-containing protein -
MMG94_RS06035 (MMG94_06020) 1214965..1215660 + 696 WP_040578828.1 MOSC domain-containing protein -
MMG94_RS06040 (MMG94_06025) 1215717..1216448 + 732 WP_016918189.1 class I SAM-dependent methyltransferase -
MMG94_RS06045 (MMG94_06030) 1216591..1217493 + 903 WP_016918190.1 EamA family transporter -
MMG94_RS06050 (MMG94_06035) 1217507..1217761 - 255 WP_016918191.1 Txe/YoeB family addiction module toxin Toxin
MMG94_RS06055 (MMG94_06040) 1217758..1218012 - 255 WP_016918192.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
MMG94_RS06060 (MMG94_06045) 1218144..1219952 - 1809 WP_016918193.1 translation elongation factor 4 -
MMG94_RS06065 (MMG94_06050) 1220197..1220856 - 660 WP_016918194.1 hypothetical protein -
MMG94_RS06070 (MMG94_06055) 1221038..1221316 - 279 WP_026016000.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10059.53 Da        Isoelectric Point: 8.4811

>T237422 WP_016918191.1 NZ_CP092968:c1217761-1217507 [Methylocystis parvus OBBP]
MKLVFAEQAWEDYLYWQSQDAKVLERINSLIKECARTPFSGTGKPEPLRGDLRGWWSRRITLEHRLVYRVEGESLLIAQC
RYHY

Download         Length: 255 bp

>T237422 NZ_LR882052:3544541-3544819 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9334.53 Da        Isoelectric Point: 5.7251

>AT237422 WP_016918192.1 NZ_CP092968:c1218012-1217758 [Methylocystis parvus OBBP]
MRTTSYSDLRKNLAATLDRVTEDHEPVVITRDRGKPAAVLISLEDFASYEETAHLLKNPRNAERLLAAIGELDAGKGVER
KLSE

Download         Length: 255 bp

>AT237422 NZ_LR882052:3544278-3544538 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B8M7C1

Antitoxin

Source ID Structure
AlphaFold DB A0A6B8M0R4

References