Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 753358..754147 Replicon chromosome
Accession NZ_CP092968
Organism Methylocystis parvus OBBP

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag MMG94_RS03725 Protein ID WP_016918666.1
Coordinates 753641..754147 (+) Length 169 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag MMG94_RS03720 Protein ID WP_016918667.1
Coordinates 753358..753648 (+) Length 97 a.a.

Genomic Context

MMG94_RS03690MMG94_RS03700MMG94_RS03705MMG94_RS03710MMG94_RS03715MMG94_RS03720MMG94_RS03725MMG94_RS03745MMG94_RS03695MMG94_RS03730MMG94_RS03735MMG94_RS03740MMG94_RS03750MMG94_RS03755
Location: 748667..749128 (462 bp)
Type: Others
Protein ID: WP_016918673.1
Location: 750258..750788 (531 bp)
Type: Others
Protein ID: WP_016918671.1
Location: 751171..751674 (504 bp)
Type: Others
Protein ID: WP_016918670.1
Location: 751722..752489 (768 bp)
Type: Others
Protein ID: WP_244415223.1
Location: 752578..753240 (663 bp)
Type: Others
Protein ID: WP_040578936.1
Location: 753358..753648 (291 bp)
Type: Antitoxin
Protein ID: WP_016918667.1
Location: 753641..754147 (507 bp)
Type: Toxin
Protein ID: WP_016918666.1
Location: 757049..757921 (873 bp)
Type: Others
Protein ID: WP_016918662.1
Location: 749139..750011 (873 bp)
Type: Others
Protein ID: WP_016918672.1
Location: 754195..755565 (1371 bp)
Type: Others
Protein ID: WP_016918665.1
Location: 755580..756344 (765 bp)
Type: Others
Protein ID: WP_016918664.1
Location: 756341..756859 (519 bp)
Type: Others
Protein ID: WP_051001081.1
Location: 758012..758494 (483 bp)
Type: Others
Protein ID: WP_020372401.1
Location: 758540..759103 (564 bp)
Type: Others
Protein ID: WP_016918660.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MMG94_RS03690 (MMG94_03675)748667..749128+462WP_016918673.1hypothetical protein-
MMG94_RS03695 (MMG94_03680)749139..750011-873WP_016918672.1methyltransferase domain-containing protein-
MMG94_RS03700 (MMG94_03685)750258..750788+531WP_016918671.1L,D-transpeptidase-
MMG94_RS03705 (MMG94_03690)751171..751674+504WP_016918670.1YbjN domain-containing protein-
MMG94_RS03710 (MMG94_03695)751722..752489+768WP_244415223.1pyrroline-5-carboxylate reductase-
MMG94_RS03715 (MMG94_03700)752578..753240+663WP_040578936.1TetR family transcriptional regulator-
MMG94_RS03720 (MMG94_03705)753358..753648+291WP_016918667.1DUF1778 domain-containing proteinAntitoxin
MMG94_RS03725 (MMG94_03710)753641..754147+507WP_016918666.1GNAT family N-acetyltransferaseToxin
MMG94_RS03730 (MMG94_03715)754195..755565-1371WP_016918665.1ATP-binding protein-
MMG94_RS03735 (MMG94_03720)755580..756344-765WP_016918664.1response regulator transcription factor-
MMG94_RS03740 (MMG94_03725)756341..756859-519WP_051001081.1MarR family transcriptional regulator-
MMG94_RS03745 (MMG94_03730)757049..757921+873WP_016918662.1branched-chain amino acid aminotransferase-
MMG94_RS03750 (MMG94_03735)758012..758494-483WP_020372401.1hypothetical protein-
MMG94_RS03755 (MMG94_03740)758540..759103-564WP_016918660.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(23-144)

Antitoxin

Vibrio phage ICP1, Orf50

(5-92)


Sequences

Toxin        


Download         Length: 169 a.a.        Molecular weight: 18258.13 Da        Isoelectric Point: 9.9196

>T237421 WP_016918666.1 NZ_CP092968:753641-754147 [Methylocystis parvus OBBP]
VNKSSSVEKLHRKHAVEEFTCGRPELDRFLIRHALQAQRMDSSRTYLGLSGEAVIGYHTIVVGQAVHADAPERVSKGMPR
HPIPLLILARLAVHIDWRGRGVGAGLLLDAMGRTLQVAEIAGVHALAVHAKDEAAAAFYAHFGFIPSPTDARHLLMPIKD
IRAAAGEK

Download         Length: 507 bp

>T237421 NZ_LR882052:c3538479-3538081 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11113.67 Da        Isoelectric Point: 6.4102

>AT237421 WP_016918667.1 NZ_CP092968:753358-753648 [Methylocystis parvus OBBP]
MITPRTTRSEKLDLRLTGEAKQMLQEAAAVAQKTVSEFVLESALSEARERLSDRRVFILDEERWVALRAALDAPPRRQPR
LEKLFSEPSFFDPNRE

Download         Length: 291 bp

>AT237421 NZ_LR882052:c3538775-3538482 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References