Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | PumAB/COG3657-dnstrm_HI1420 |
Location | 780985..781565 | Replicon | chromosome |
Accession | NZ_CP092923 | ||
Organism | Pseudomonas syringae pv. tagetis strain ICMP 4091 |
Toxin (Protein)
Gene name | PumA | Uniprot ID | A0A0Q0EIR5 |
Locus tag | MME58_RS03455 | Protein ID | WP_032620802.1 |
Coordinates | 780985..781284 (+) | Length | 100 a.a. |
Antitoxin (Protein)
Gene name | PumB | Uniprot ID | A0A2G4CUT8 |
Locus tag | MME58_RS03460 | Protein ID | WP_003407168.1 |
Coordinates | 781281..781565 (+) | Length | 95 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MME58_RS03425 (MME58_03425) | 777115..777795 | + | 681 | WP_054986846.1 | hypothetical protein | - |
MME58_RS03430 (MME58_03430) | 778241..778426 | + | 186 | WP_221041297.1 | phosphoribulokinase | - |
MME58_RS03435 (MME58_03435) | 778663..778914 | - | 252 | WP_003348789.1 | ribbon-helix-helix protein, CopG family | - |
MME58_RS03440 (MME58_03440) | 779003..779656 | - | 654 | WP_054986844.1 | AAA family ATPase | - |
MME58_RS03445 (MME58_03445) | 780051..780467 | - | 417 | WP_055005949.1 | hypothetical protein | - |
MME58_RS03450 (MME58_03450) | 780526..780813 | - | 288 | WP_041924941.1 | hypothetical protein | - |
MME58_RS03455 (MME58_03455) | 780985..781284 | + | 300 | WP_032620802.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
MME58_RS03460 (MME58_03460) | 781281..781565 | + | 285 | WP_003407168.1 | putative addiction module antidote protein | Antitoxin |
MME58_RS03470 (MME58_03470) | 781980..782319 | - | 340 | Protein_678 | DUF4113 domain-containing protein | - |
MME58_RS03475 (MME58_03475) | 782342..784693 | + | 2352 | WP_169790335.1 | Tn3 family transposase | - |
MME58_RS03480 (MME58_03480) | 784792..786015 | - | 1224 | WP_055005951.1 | type III secretion system effector HopQ1-1 | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | pilR | 704666..794493 | 89827 | |
- | flank | IS/Tn | - | - | 782342..784693 | 2351 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11140.78 Da Isoelectric Point: 10.1771
>T237419 WP_032620802.1 NZ_CP092923:780985-781284 [Pseudomonas syringae pv. tagetis]
MTTIKQTSTYMAWERRLKDQKAKAAIAARIFRVANGLMGDVSPVGQGVSELRIHVGPGYRVYFQQRGDELILLLCGGDKS
SQSRDIETAKKLADQWRQE
MTTIKQTSTYMAWERRLKDQKAKAAIAARIFRVANGLMGDVSPVGQGVSELRIHVGPGYRVYFQQRGDELILLLCGGDKS
SQSRDIETAKKLADQWRQE
Download Length: 300 bp
>T237419 NZ_LR882052:2577818-2577925 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10277.83 Da Isoelectric Point: 5.0916
>AT237419 WP_003407168.1 NZ_CP092923:781281-781565 [Pseudomonas syringae pv. tagetis]
MKEQIFDYDPAAALDGPEAIAIFISDAFETGDAEYIAKAMGVVARAKGMTELARETGLSREQLYRSFSSKGNPTLKTMLT
VMRALGVDMTARMH
MKEQIFDYDPAAALDGPEAIAIFISDAFETGDAEYIAKAMGVVARAKGMTELARETGLSREQLYRSFSSKGNPTLKTMLT
VMRALGVDMTARMH
Download Length: 285 bp
>AT237419 NZ_LR882052:c2577771-2577705 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0Q0EIR5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2G4CUT8 |