Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1149309..1149957 Replicon chromosome
Accession NZ_CP092915
Organism Mycolicibacterium sp. YH-1

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag L0M16_RS05340 Protein ID WP_241403268.1
Coordinates 1149529..1149957 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag L0M16_RS05335 Protein ID WP_241403267.1
Coordinates 1149309..1149524 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0M16_RS05325 (L0M16_05325) 1145269..1146885 + 1617 WP_241403265.1 serine hydrolase domain-containing protein -
L0M16_RS05330 (L0M16_05330) 1146882..1149272 + 2391 WP_241403266.1 cation-translocating P-type ATPase -
L0M16_RS05335 (L0M16_05335) 1149309..1149524 + 216 WP_241403267.1 antitoxin Antitoxin
L0M16_RS05340 (L0M16_05340) 1149529..1149957 + 429 WP_241403268.1 SRPBCC family protein Toxin
L0M16_RS05345 (L0M16_05345) 1150013..1151410 + 1398 WP_241403269.1 NAD-dependent succinate-semialdehyde dehydrogenase -
L0M16_RS05350 (L0M16_05350) 1151429..1152319 + 891 WP_241405480.1 amidohydrolase family protein -
L0M16_RS05355 (L0M16_05355) 1152398..1153186 + 789 WP_241403270.1 VOC family protein -
L0M16_RS05360 (L0M16_05360) 1153161..1153622 - 462 WP_241403271.1 cupin domain-containing protein -
L0M16_RS05365 (L0M16_05365) 1153671..1154105 + 435 WP_241403272.1 hypothetical protein -
L0M16_RS05370 (L0M16_05370) 1154102..1154722 + 621 WP_241403273.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-141)

Antitoxin

Antitoxin Rv0909/MT0933

(4-52)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15438.92 Da        Isoelectric Point: 9.8961

>T237413 WP_241403268.1 NZ_CP092915:1149529-1149957 [Mycolicibacterium sp. YH-1]
MAKLSVSVDVPMSPDQAWEAASDLSRYKEWLTVHRVWRNALPETIGKGTELVSIIEVKGMANRVTWKIVNYRPPESMTLN
GDGKGGVKIKLIAKITPTETGSTVRFDVHLGGVLFGPIGMAVAGALKGDIQQSLENFKTVFA

Download         Length: 429 bp

>T237413 NZ_LR882052:1940991-1941094 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7598.48 Da        Isoelectric Point: 7.0067

>AT237413 WP_241403267.1 NZ_CP092915:1149309-1149524 [Mycolicibacterium sp. YH-1]
MGFLDKVKNLVSQNADKVDSAIDKVGDIVDQKTQGKYTQHVDKVQEAAKKAVDNTQQPGQPPASPPAPPQS

Download         Length: 216 bp

>AT237413 NZ_LR882052:c1941132-1940861 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References