Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4429465..4430225 | Replicon | chromosome |
| Accession | NZ_CP092911 | ||
| Organism | Salmonella enterica subsp. enterica strain SR33 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | A0A620G002 |
| Locus tag | MLD58_RS21770 | Protein ID | WP_023138210.1 |
| Coordinates | 4429465..4429950 (-) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | Q8Z2B2 |
| Locus tag | MLD58_RS21775 | Protein ID | WP_000965889.1 |
| Coordinates | 4429938..4430225 (-) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MLD58_RS21740 (4424527) | 4424527..4425189 | + | 663 | WP_000747548.1 | OmpA family lipoprotein | - |
| MLD58_RS21745 (4425419) | 4425419..4426393 | + | 975 | WP_023138208.1 | glyoxylate/hydroxypyruvate reductase GhrB | - |
| MLD58_RS21750 (4426443) | 4426443..4427153 | - | 711 | WP_023138209.1 | DUF3053 domain-containing protein | - |
| MLD58_RS21755 (4427592) | 4427592..4427882 | + | 291 | WP_000455790.1 | HTH-type transcriptional regulator | - |
| MLD58_RS21760 (4428170) | 4428170..4428382 | + | 213 | WP_000014594.1 | RNA chaperone/antiterminator CspA | - |
| MLD58_RS21765 (4428555) | 4428555..4429094 | + | 540 | WP_000047148.1 | copper-binding periplasmic metallochaperone CueP | - |
| MLD58_RS21770 (4429465) | 4429465..4429950 | - | 486 | WP_023138210.1 | GNAT family N-acetyltransferase | Toxin |
| MLD58_RS21775 (4429938) | 4429938..4430225 | - | 288 | WP_000965889.1 | DUF1778 domain-containing protein | Antitoxin |
| MLD58_RS21780 (4430437) | 4430437..4430682 | + | 246 | WP_023138211.1 | hypothetical protein | - |
| MLD58_RS21785 (4430739) | 4430739..4431362 | + | 624 | WP_000082043.1 | hypothetical protein | - |
| MLD58_RS21790 (4431603) | 4431603..4431940 | + | 338 | Protein_4262 | tyrosine-type recombinase/integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17643.31 Da Isoelectric Point: 9.8719
>T237406 WP_023138210.1 NZ_CP092911:c4429950-4429465 [Salmonella enterica subsp. enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSSHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSSHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
Download Length: 486 bp
>T237406 NZ_LR882052:c605005-604541 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGTTCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGTTCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10964.59 Da Isoelectric Point: 4.6811
>AT237406 WP_000965889.1 NZ_CP092911:c4430225-4429938 [Salmonella enterica subsp. enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
Download Length: 288 bp
>AT237406 NZ_LR882052:c605340-605005 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A620G002 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A752RW74 |