Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4254321..4254907 Replicon chromosome
Accession NZ_CP092911
Organism Salmonella enterica subsp. enterica strain SR33

Toxin (Protein)


Gene name doc Uniprot ID A0A5T2TYR8
Locus tag MLD58_RS20970 Protein ID WP_023138592.1
Coordinates 4254321..4254689 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID M7SDJ3
Locus tag MLD58_RS20975 Protein ID WP_001520924.1
Coordinates 4254686..4254907 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MLD58_RS20950 (4249840) 4249840..4250910 - 1071 WP_001646570.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -
MLD58_RS20955 (4250912) 4250912..4251757 - 846 WP_000572196.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
MLD58_RS20960 (4251754) 4251754..4252641 - 888 WP_023138593.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
MLD58_RS20965 (4252746) 4252746..4254062 - 1317 WP_000624747.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
MLD58_RS20970 (4254321) 4254321..4254689 - 369 WP_023138592.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
MLD58_RS20975 (4254686) 4254686..4254907 - 222 WP_001520924.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MLD58_RS20980 (4255039) 4255039..4255752 - 714 WP_000416114.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
MLD58_RS20985 (4255754) 4255754..4256521 - 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
MLD58_RS20990 (4256518) 4256518..4257795 - 1278 WP_000803764.1 branched chain amino acid ABC transporter permease LivM -
MLD58_RS20995 (4257792) 4257792..4258718 - 927 WP_000003007.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
MLD58_RS21000 (4258778) 4258778..4259887 - 1110 WP_000822977.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4249103..4256521 7418


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(25-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13563.81 Da        Isoelectric Point: 6.7252

>T237405 WP_023138592.1 NZ_CP092911:c4254689-4254321 [Salmonella enterica subsp. enterica]
MTLQLISAEEIIQFHDRLLRVTPGVTGMSDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA

Download         Length: 369 bp

>T237405 NZ_LR882052:180780-180887 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8152.14 Da        Isoelectric Point: 5.0775

>AT237405 WP_001520924.1 NZ_CP092911:c4254907-4254686 [Salmonella enterica subsp. enterica]
MRTVNYSEARQNLAEVLESAVTGGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Download         Length: 222 bp

>AT237405 NZ_LR882052:c180731-180668 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5T2TYR8

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6Z871

References