Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3733225..3733885 Replicon chromosome
Accession NZ_CP092911
Organism Salmonella enterica subsp. enterica strain SR33

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag MLD58_RS18335 Protein ID WP_000244756.1
Coordinates 3733225..3733638 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag MLD58_RS18340 Protein ID WP_000351186.1
Coordinates 3733619..3733885 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MLD58_RS18315 (3729166) 3729166..3730899 - 1734 WP_000813387.1 single-stranded-DNA-specific exonuclease RecJ -
MLD58_RS18320 (3730905) 3730905..3731618 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MLD58_RS18325 (3731642) 3731642..3732538 - 897 WP_000434303.1 site-specific tyrosine recombinase XerD -
MLD58_RS18330 (3732651) 3732651..3733172 + 522 WP_001055885.1 flavodoxin FldB -
MLD58_RS18335 (3733225) 3733225..3733638 - 414 WP_000244756.1 protein YgfX Toxin
MLD58_RS18340 (3733619) 3733619..3733885 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
MLD58_RS18345 (3734135) 3734135..3735115 + 981 WP_000874176.1 tRNA-modifying protein YgfZ -
MLD58_RS18350 (3735231) 3735231..3735890 - 660 WP_000250289.1 hemolysin III family protein -
MLD58_RS18355 (3736054) 3736054..3736365 - 312 WP_001182970.1 N(4)-acetylcytidine aminohydrolase -
MLD58_RS18360 (3736524) 3736524..3737957 + 1434 WP_001230140.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T237404 WP_000244756.1 NZ_CP092911:c3733638-3733225 [Salmonella enterica subsp. enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T237404 NZ_LR882051:7354-7734 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT237404 WP_000351186.1 NZ_CP092911:c3733885-3733619 [Salmonella enterica subsp. enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT237404 NZ_LR882051:7133-7354 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References