Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 3565828..3566642 | Replicon | chromosome |
| Accession | NZ_CP092911 | ||
| Organism | Salmonella enterica subsp. enterica strain SR33 | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | A0A3G3DUX8 |
| Locus tag | MLD58_RS17580 | Protein ID | WP_000971653.1 |
| Coordinates | 3566115..3566642 (+) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | M7S6I2 |
| Locus tag | MLD58_RS17575 | Protein ID | WP_000855694.1 |
| Coordinates | 3565828..3566118 (+) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MLD58_RS17545 (3561769) | 3561769..3562419 | - | 651 | WP_023166786.1 | type III secretion system transcriptional activator InvF | - |
| MLD58_RS17550 (3562876) | 3562876..3563319 | + | 444 | WP_000715096.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
| MLD58_RS17555 (3563738) | 3563738..3564187 | + | 450 | WP_000381616.1 | hypothetical protein | - |
| MLD58_RS17560 (3564172) | 3564172..3564519 | + | 348 | WP_001555786.1 | DUF1493 family protein | - |
| MLD58_RS17565 (3564791) | 3564791..3565117 | - | 327 | WP_000393297.1 | hypothetical protein | - |
| MLD58_RS17570 (3565358) | 3565358..3565558 | + | 201 | Protein_3434 | IS3 family transposase | - |
| MLD58_RS17575 (3565828) | 3565828..3566118 | + | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
| MLD58_RS17580 (3566115) | 3566115..3566642 | + | 528 | WP_000971653.1 | GNAT family N-acetyltransferase | Toxin |
| MLD58_RS17585 (3566715) | 3566715..3566917 | - | 203 | Protein_3437 | IS5/IS1182 family transposase | - |
| MLD58_RS17590 (3567267) | 3567267..3567923 | + | 657 | WP_000420449.1 | protein-serine/threonine phosphatase | - |
| MLD58_RS17595 (3568168) | 3568168..3568662 | - | 495 | WP_000424947.1 | hypothetical protein | - |
| MLD58_RS17600 (3568689) | 3568689..3569357 | - | 669 | WP_023137848.1 | hypothetical protein | - |
| MLD58_RS17605 (3569514) | 3569514..3569732 | - | 219 | Protein_3441 | hypothetical protein | - |
| MLD58_RS17610 (3569943) | 3569943..3570341 | - | 399 | Protein_3442 | cytoplasmic protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 3566715..3566855 | 140 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19043.87 Da Isoelectric Point: 9.7032
>T237403 WP_000971653.1 NZ_CP092911:3566115-3566642 [Salmonella enterica subsp. enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
>T237403 NZ_LR882050:4108936-4109271 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT237403 WP_000855694.1 NZ_CP092911:3565828-3566118 [Salmonella enterica subsp. enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
>AT237403 NZ_LR882050:4108688-4108936 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3G3DUX8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V8SJE7 |