237393

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2151241..2151763 Replicon chromosome
Accession NZ_CP092911
Organism Salmonella enterica subsp. enterica strain SR33

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag MLD58_RS10525 Protein ID WP_000221345.1
Coordinates 2151241..2151525 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag MLD58_RS10530 Protein ID WP_000885424.1
Coordinates 2151515..2151763 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MLD58_RS10505 (2147316) 2147316..2148824 - 1509 WP_023138146.1 FAD-dependent oxidoreductase -
MLD58_RS10510 (2148869) 2148869..2149357 + 489 WP_023138147.1 MarR family winged helix-turn-helix transcriptional regulator -
MLD58_RS10515 (2149550) 2149550..2150623 + 1074 WP_023138148.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
MLD58_RS10520 (2150681) 2150681..2151070 - 390 WP_000194089.1 RidA family protein -
MLD58_RS10525 (2151241) 2151241..2151525 - 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MLD58_RS10530 (2151515) 2151515..2151763 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MLD58_RS10535 (2152176) 2152176..2152529 - 354 WP_000418733.1 hypothetical protein -
MLD58_RS10540 (2152532) 2152532..2152921 - 390 WP_001044696.1 hypothetical protein -
MLD58_RS10545 (2153286) 2153286..2153393 + 108 Protein_2060 IS110 family transposase -
MLD58_RS10550 (2153800) 2153800..2154132 + 333 WP_023138149.1 DUF1493 family protein -
MLD58_RS10555 (2154407) 2154407..2154595 - 189 WP_001276021.1 DUF29 family protein -
MLD58_RS10560 (2155008) 2155008..2155916 + 909 WP_023138150.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T237393 WP_000221345.1 NZ_CP092911:c2151525-2151241 [Salmonella enterica subsp. enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

>T237393 NZ_LR882050:c2639006-2638833 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT237393 WP_000885424.1 NZ_CP092911:c2151763-2151515 [Salmonella enterica subsp. enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT237393 NZ_LR882050:c2639330-2639034 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References