Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1095663..1096283 Replicon chromosome
Accession NZ_CP092911
Organism Salmonella enterica subsp. enterica strain SR33

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag MLD58_RS05160 Protein ID WP_001280991.1
Coordinates 1095663..1095881 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag MLD58_RS05165 Protein ID WP_000344807.1
Coordinates 1095909..1096283 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MLD58_RS05120 (1090887) 1090887..1091456 + 570 WP_000779802.1 YbaY family lipoprotein -
MLD58_RS05125 (1091489) 1091489..1091878 - 390 WP_000961285.1 MGMT family protein -
MLD58_RS05135 (1092109) 1092109..1093659 - 1551 WP_000213144.1 EAL domain-containing protein -
MLD58_RS05140 (1093884) 1093884..1094144 + 261 WP_000801421.1 type B 50S ribosomal protein L31 -
MLD58_RS05145 (1094150) 1094150..1094290 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
MLD58_RS05150 (1094345) 1094345..1094815 - 471 WP_000136183.1 YlaC family protein -
MLD58_RS05155 (1094933) 1094933..1095484 - 552 WP_001278793.1 maltose O-acetyltransferase -
MLD58_RS05160 (1095663) 1095663..1095881 - 219 WP_001280991.1 HHA domain-containing protein Toxin
MLD58_RS05165 (1095909) 1095909..1096283 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
MLD58_RS05170 (1096779) 1096779..1099928 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
MLD58_RS05175 (1099951) 1099951..1101144 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T237392 WP_001280991.1 NZ_CP092911:c1095881-1095663 [Salmonella enterica subsp. enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T237392 NZ_LR882050:2083976-2084254 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTATTTGGGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT237392 WP_000344807.1 NZ_CP092911:c1096283-1095909 [Salmonella enterica subsp. enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT237392 NZ_LR882050:2083713-2083973 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAAGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATTAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References