Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 448154..448730 Replicon chromosome
Accession NZ_CP092911
Organism Salmonella enterica subsp. enterica strain SR33

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag MLD58_RS02110 Protein ID WP_001131963.1
Coordinates 448154..448441 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A6C6ZAR7
Locus tag MLD58_RS02115 Protein ID WP_000063143.1
Coordinates 448428..448730 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MLD58_RS02100 (443264) 443264..446773 - 3510 WP_023138516.1 type I restriction-modification system endonuclease -
MLD58_RS02105 (446971) 446971..447885 + 915 WP_023138517.1 restriction endonuclease -
MLD58_RS02110 (448154) 448154..448441 + 288 WP_001131963.1 BrnT family toxin Toxin
MLD58_RS02115 (448428) 448428..448730 + 303 WP_000063143.1 BrnA antitoxin family protein Antitoxin
MLD58_RS02120 (448805) 448805..449761 - 957 WP_000187840.1 GTPase -
MLD58_RS02125 (449772) 449772..449975 - 204 WP_000460616.1 YbdD/YjiX family protein -
MLD58_RS02130 (450070) 450070..452220 - 2151 WP_000379928.1 pyruvate/proton symporter BtsT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(40-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T237391 WP_001131963.1 NZ_CP092911:448154-448441 [Salmonella enterica subsp. enterica]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T237391 NZ_LR882050:c2077922-2077524 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11402.01 Da        Isoelectric Point: 10.1293

>AT237391 WP_000063143.1 NZ_CP092911:448428-448730 [Salmonella enterica subsp. enterica]
MSMVKHKRGNASALSAQHEAELKALVKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT237391 NZ_LR882050:c2078218-2077925 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6ZAR7

References