Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 399913..400463 Replicon chromosome
Accession NZ_CP092911
Organism Salmonella enterica subsp. enterica strain SR33

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag MLD58_RS01925 Protein ID WP_001199743.1
Coordinates 400155..400463 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag MLD58_RS01920 Protein ID WP_001118105.1
Coordinates 399913..400152 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MLD58_RS01875 (394962) 394962..395165 + 204 WP_023137300.1 hypothetical protein -
MLD58_RS01880 (395230) 395230..396144 + 915 WP_023138490.1 hypothetical protein -
MLD58_RS01885 (396229) 396229..397050 + 822 WP_023138491.1 DUF932 domain-containing protein -
MLD58_RS01890 (397063) 397063..397563 + 501 WP_023138492.1 DNA repair protein RadC -
MLD58_RS01895 (397560) 397560..397781 + 222 WP_023138493.1 DUF987 family protein -
MLD58_RS01900 (397804) 397804..398145 + 342 WP_023138494.1 type IV toxin-antitoxin system YeeU family antitoxin -
MLD58_RS01905 (398189) 398189..398530 + 342 WP_023138495.1 TA system toxin CbtA family protein -
MLD58_RS01910 (398646) 398646..399479 + 834 WP_023138496.1 DUF4942 domain-containing protein -
MLD58_RS01915 (399556) 399556..399804 + 249 WP_000168385.1 ribbon-helix-helix domain-containing protein -
MLD58_RS01920 (399913) 399913..400152 + 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
MLD58_RS01925 (400155) 400155..400463 + 309 WP_001199743.1 CcdB family protein Toxin
MLD58_RS01930 (400587) 400587..401569 - 983 Protein_370 IS3 family transposase -
MLD58_RS01935 (401636) 401636..402653 + 1018 Protein_371 IS110 family transposase -
MLD58_RS01940 (402879) 402879..402995 - 117 Protein_372 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T237390 WP_001199743.1 NZ_CP092911:400155-400463 [Salmonella enterica subsp. enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T237390 NZ_LR882050:1845081-1845299 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT237390 WP_001118105.1 NZ_CP092911:399913-400152 [Salmonella enterica subsp. enterica]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT237390 NZ_LR882050:1844681-1845055 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTTCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References