Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | ykfI-yfjZ/CbtA-CbeA |
| Location | 397804..398530 | Replicon | chromosome |
| Accession | NZ_CP092911 | ||
| Organism | Salmonella enterica subsp. enterica strain SR33 | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | A0A5T2TVB7 |
| Locus tag | MLD58_RS01905 | Protein ID | WP_023138495.1 |
| Coordinates | 398189..398530 (+) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | A0A5T2TUW7 |
| Locus tag | MLD58_RS01900 | Protein ID | WP_023138494.1 |
| Coordinates | 397804..398145 (+) | Length | 114 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MLD58_RS01860 (393365) | 393365..393658 | + | 294 | WP_023138487.1 | hypothetical protein | - |
| MLD58_RS01865 (394013) | 394013..394726 | + | 714 | WP_023138489.1 | WYL domain-containing protein | - |
| MLD58_RS01870 (394799) | 394799..394945 | + | 147 | WP_023892166.1 | hypothetical protein | - |
| MLD58_RS01875 (394962) | 394962..395165 | + | 204 | WP_023137300.1 | hypothetical protein | - |
| MLD58_RS01880 (395230) | 395230..396144 | + | 915 | WP_023138490.1 | hypothetical protein | - |
| MLD58_RS01885 (396229) | 396229..397050 | + | 822 | WP_023138491.1 | DUF932 domain-containing protein | - |
| MLD58_RS01890 (397063) | 397063..397563 | + | 501 | WP_023138492.1 | DNA repair protein RadC | - |
| MLD58_RS01895 (397560) | 397560..397781 | + | 222 | WP_023138493.1 | DUF987 family protein | - |
| MLD58_RS01900 (397804) | 397804..398145 | + | 342 | WP_023138494.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| MLD58_RS01905 (398189) | 398189..398530 | + | 342 | WP_023138495.1 | TA system toxin CbtA family protein | Toxin |
| MLD58_RS01910 (398646) | 398646..399479 | + | 834 | WP_023138496.1 | DUF4942 domain-containing protein | - |
| MLD58_RS01915 (399556) | 399556..399804 | + | 249 | WP_000168385.1 | ribbon-helix-helix domain-containing protein | - |
| MLD58_RS01920 (399913) | 399913..400152 | + | 240 | WP_001118105.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| MLD58_RS01925 (400155) | 400155..400463 | + | 309 | WP_001199743.1 | CcdB family protein | - |
| MLD58_RS01930 (400587) | 400587..401569 | - | 983 | Protein_370 | IS3 family transposase | - |
| MLD58_RS01935 (401636) | 401636..402653 | + | 1018 | Protein_371 | IS110 family transposase | - |
| MLD58_RS01940 (402879) | 402879..402995 | - | 117 | Protein_372 | transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 13132.05 Da Isoelectric Point: 9.7617
>T237389 WP_023138495.1 NZ_CP092911:398189-398530 [Salmonella enterica subsp. enterica]
MQTQYNHPHRATPSQLSPVEIWQKLLTHLLAKHYGLELSDTPFSVEKVIQEHIDAGITLANAVNFIVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRRQRYLAAH
MQTQYNHPHRATPSQLSPVEIWQKLLTHLLAKHYGLELSDTPFSVEKVIQEHIDAGITLANAVNFIVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRRQRYLAAH
Download Length: 342 bp
>T237389 NZ_LR882050:1473176-1473562 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGTAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGTAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA
Antitoxin
Download Length: 114 a.a. Molecular weight: 12690.40 Da Isoelectric Point: 6.2121
>AT237389 WP_023138494.1 NZ_CP092911:397804-398145 [Salmonella enterica subsp. enterica]
MDTNETQSTPVWGLRNDVFPSFGARLVQEGNHLHYLADRAGIYGEFTPAQLQTLDVVFPMFIKHMEAALRTGALNPREAR
RFTTELRGITCEADTCGSFGYVYLSLYPTIVKS
MDTNETQSTPVWGLRNDVFPSFGARLVQEGNHLHYLADRAGIYGEFTPAQLQTLDVVFPMFIKHMEAALRTGALNPREAR
RFTTELRGITCEADTCGSFGYVYLSLYPTIVKS
Download Length: 342 bp
>AT237389 NZ_LR882050:1473552-1473881 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCATTGGGCCTGATGTCTGATAGTGAGGTTGA
TGCCATTGCCGTCATGGTCAAAGCCCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCATTGGGCCTGATGTCTGATAGTGAGGTTGA
TGCCATTGCCGTCATGGTCAAAGCCCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5T2TVB7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5T2TUW7 |