Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 336808..337324 Replicon chromosome
Accession NZ_CP092911
Organism Salmonella enterica subsp. enterica strain SR33

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag MLD58_RS01585 Protein ID WP_000220578.1
Coordinates 337040..337324 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag MLD58_RS01580 Protein ID WP_000212724.1
Coordinates 336808..337050 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MLD58_RS01560 (331828) 331828..332961 + 1134 WP_023138829.1 amidohydrolase/deacetylase family metallohydrolase -
MLD58_RS01565 (332945) 332945..334063 + 1119 WP_023138828.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
MLD58_RS01570 (334060) 334060..334800 + 741 WP_023138827.1 KDGP aldolase family protein -
MLD58_RS01575 (334817) 334817..336730 + 1914 WP_023203318.1 BglG family transcription antiterminator -
MLD58_RS01580 (336808) 336808..337050 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MLD58_RS01585 (337040) 337040..337324 + 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MLD58_RS01590 (337328) 337328..337792 - 465 WP_017441190.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MLD58_RS01595 (338009) 338009..340147 - 2139 WP_241371378.1 anaerobic ribonucleoside-triphosphate reductase -
MLD58_RS01600 (340556) 340556..342208 - 1653 WP_023138463.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T237388 WP_000220578.1 NZ_CP092911:337040-337324 [Salmonella enterica subsp. enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T237388 NZ_LR882050:1063481-1063588 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGGACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT237388 WP_000212724.1 NZ_CP092911:336808-337050 [Salmonella enterica subsp. enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT237388 NZ_LR882050:c1063431-1063368 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References