237387

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 61643..62214 Replicon plasmid unnamed1
Accession NZ_CP092908
Organism Enterococcus faecalis strain LJX 0909

Toxin (Protein)


Gene name mazF Uniprot ID S4H3R9
Locus tag MK744_RS13795 Protein ID WP_010784114.1
Coordinates 61643..61984 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3KHK9
Locus tag MK744_RS13800 Protein ID WP_002362431.1
Coordinates 61984..62214 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MK744_RS13775 (MK744_13775) 57042..58325 - 1284 WP_002405123.1 hypothetical protein -
MK744_RS13785 (MK744_13785) 59726..60328 - 603 WP_002362434.1 Fic family protein -
MK744_RS13790 (MK744_13790) 60593..61531 - 939 WP_002362433.1 hypothetical protein -
MK744_RS13795 (MK744_13795) 61643..61984 - 342 WP_010784114.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MK744_RS13800 (MK744_13800) 61984..62214 - 231 WP_002362431.1 hypothetical protein Antitoxin
MK744_RS13805 (MK744_13805) 62418..63038 + 621 WP_202584301.1 recombinase family protein -
MK744_RS13810 (MK744_13810) 63028..63342 + 315 WP_202584302.1 hypothetical protein -
MK744_RS13815 (MK744_13815) 63336..63560 + 225 WP_202584303.1 hypothetical protein -
MK744_RS13820 (MK744_13820) 63622..63831 + 210 WP_002363054.1 hypothetical protein -
MK744_RS13825 (MK744_13825) 64173..64424 + 252 WP_010711381.1 hypothetical protein -
MK744_RS13830 (MK744_13830) 64478..64915 - 438 WP_202317972.1 hypothetical protein -
MK744_RS13835 (MK744_13835) 65006..65257 + 252 WP_202584304.1 hypothetical protein -
MK744_RS13840 (MK744_13840) 65373..66688 + 1316 Protein_67 Y-family DNA polymerase -
MK744_RS13845 (MK744_13845) 66692..67198 + 507 WP_202584307.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid ClpL - 1..109589 109589


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13270.47 Da        Isoelectric Point: 7.9750

>T237387 WP_010784114.1 NZ_CP092908:c61984-61643 [Enterococcus faecalis]
MSDEKKYIPKKGDIVWIDFDPSAEKEIQKRRPGLVVSRYEFNRKTLFAVICPITSTIKNMPTRYTLPDEMETHGQVVISQ
LKSLDFAERKLSQIEYLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

>T237387 NZ_LR882050:1062946-1063053 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8510.42 Da        Isoelectric Point: 4.3855

>AT237387 WP_002362431.1 NZ_CP092908:c62214-61984 [Enterococcus faecalis]
MLTTKSRKQGSSVVLTLPSNNGQKPKADQEYIVMYSDDGTITLVPKLQDPFSGGSEGEYYEKDEWHDIEPGGRELF

Download         Length: 231 bp

>AT237387 NZ_LR882050:c1062899-1062833 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4H3R9

Antitoxin

Source ID Structure
AlphaFold DB R3KHK9

References