237362

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 2340326..2341012 Replicon chromosome
Accession NZ_CP092907
Organism Enterococcus faecalis strain LJX 0909

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag MK744_RS11295 Protein ID WP_241408231.1
Coordinates 2340668..2341012 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag MK744_RS11290 Protein ID WP_010707137.1
Coordinates 2340326..2340649 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MK744_RS11230 (2335938) 2335938..2336954 - 1017 WP_241408226.1 RecT family recombinase -
MK744_RS11235 (2337029) 2337029..2337334 - 306 WP_241408227.1 hypothetical protein -
MK744_RS11240 (2337385) 2337385..2337639 + 255 WP_241408228.1 hypothetical protein -
MK744_RS11245 (2337614) 2337614..2337832 - 219 WP_048968712.1 hypothetical protein -
MK744_RS11250 (2337926) 2337926..2338282 - 357 WP_010774955.1 hypothetical protein -
MK744_RS11255 (2338285) 2338285..2338509 - 225 WP_002358104.1 hypothetical protein -
MK744_RS11260 (2338506) 2338506..2338805 - 300 WP_010706856.1 hypothetical protein -
MK744_RS11265 (2338872) 2338872..2339051 - 180 WP_241408229.1 hypothetical protein -
MK744_RS11270 (2339086) 2339086..2339355 - 270 WP_002367284.1 hypothetical protein -
MK744_RS11275 (2339371) 2339371..2339547 - 177 WP_002367285.1 helix-turn-helix domain-containing protein -
MK744_RS11280 (2339631) 2339631..2339840 + 210 WP_010707139.1 hypothetical protein -
MK744_RS11285 (2339837) 2339837..2340019 - 183 WP_241408230.1 hypothetical protein -
MK744_RS11290 (2340326) 2340326..2340649 + 324 WP_010707137.1 helix-turn-helix transcriptional regulator Antitoxin
MK744_RS11295 (2340668) 2340668..2341012 + 345 WP_241408231.1 ImmA/IrrE family metallo-endopeptidase Toxin
MK744_RS11300 (2341070) 2341070..2341798 + 729 WP_002385631.1 potassium channel family protein -
MK744_RS11305 (2341953) 2341953..2343134 + 1182 WP_241408232.1 site-specific integrase -
MK744_RS11310 (2343237) 2343237..2343386 - 150 WP_002356321.1 50S ribosomal protein L33 -
MK744_RS11315 (2343512) 2343512..2345647 - 2136 WP_002379791.1 penicillin-binding protein 2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2300568..2343134 42566


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(21-86)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-59)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13582.56 Da        Isoelectric Point: 5.6177

>T237362 WP_241408231.1 NZ_CP092907:2340668-2341012 [Enterococcus faecalis]
MKSIKELVEEYNVELVFTTLNKRACFDPTYGIIFVNQNLTPSEQEEAIYHELKHVKDHVDIMALYKVPVFRSKMESEAEQ
YMFRSLIEKYEGQYNYSNVIAHYNLKMGQEVYLK

Download         Length: 345 bp

>T237362 NZ_LR881940:1756996-1757250 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCTCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCTACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12278.84 Da        Isoelectric Point: 5.2423

>AT237362 WP_010707137.1 NZ_CP092907:2340326-2340649 [Enterococcus faecalis]
MTVFDRVKKLADSQKISIVELEEKLNFSRNSLYAWKKSKPSIDKLEAVANYFGVSTDYLLGREVSNKSKQSDDLDDVLDN
VMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 324 bp

>AT237362 NZ_LR881940:1756748-1756999 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References