237355

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 141825..142347 Replicon plasmid pA_F11
Accession NZ_CP092902
Organism Klebsiella pneumoniae strain F11

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag F11wdg_RS26460 Protein ID WP_004181778.1
Coordinates 142063..142347 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag F11wdg_RS26455 Protein ID WP_004181777.1
Coordinates 141825..142073 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F11wdg_RS26435 137034..137855 - 822 WP_004181772.1 hypothetical protein -
F11wdg_RS26440 137917..138270 - 354 WP_004181774.1 hypothetical protein -
F11wdg_RS26445 (F11wdg_pA0137) 138415..139401 - 987 WP_101992392.1 hypothetical protein -
F11wdg_RS26450 (F11wdg_pA0138) 139735..141534 - 1800 WP_004181776.1 ATP-dependent helicase -
F11wdg_RS26455 (F11wdg_pA0139) 141825..142073 + 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
F11wdg_RS26460 (F11wdg_pA0140) 142063..142347 + 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F11wdg_RS26465 142364..142465 - 102 Protein_152 IS200/IS605 family transposase -
F11wdg_RS26470 (F11wdg_pA0141) 142501..143727 + 1227 WP_040209639.1 RNA-guided endonuclease TnpB family protein -
F11wdg_RS26475 (F11wdg_pA0142) 143998..144222 - 225 Protein_154 transposase -
F11wdg_RS26480 (F11wdg_pA0143) 144301..144729 - 429 WP_077257669.1 IS200/IS605 family transposase -
F11wdg_RS26485 (F11wdg_pA0144) 144765..145952 + 1188 WP_040209642.1 RNA-guided endonuclease TnpB family protein -
F11wdg_RS26490 (F11wdg_pA0145) 145997..146368 - 372 WP_040209644.1 hypothetical protein -
F11wdg_RS26495 (F11wdg_pA0146) 146365..146709 - 345 WP_223811496.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaCTX-M-14 / qacE / catB3 / blaOXA-1 / fosE - 1..221757 221757


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T237355 WP_004181778.1 NZ_CP092902:142063-142347 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

>T237355 NZ_LR881940:198123-198230 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT237355 WP_004181777.1 NZ_CP092902:141825-142073 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT237355 NZ_LR881940:c198075-198009 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References