Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 90379..91130 Replicon plasmid pA_F11
Accession NZ_CP092902
Organism Klebsiella pneumoniae strain F11

Toxin (Protein)


Gene name ataT Uniprot ID H6U1U8
Locus tag F11wdg_RS26155 Protein ID WP_014386536.1
Coordinates 90379..90861 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag F11wdg_RS26160 Protein ID WP_004902250.1
Coordinates 90852..91130 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F11wdg_RS26135 (F11wdg_pA0086) 86748..87395 - 648 WP_014386537.1 EcsC family protein -
F11wdg_RS26140 87422..88177 - 756 WP_004902235.1 DUF2971 domain-containing protein -
F11wdg_RS26145 88278..88670 - 393 WP_032442757.1 hypothetical protein -
F11wdg_RS26150 (F11wdg_pA0087) 88775..89314 - 540 WP_004902239.1 hypothetical protein -
F11wdg_RS26155 (F11wdg_pA0089) 90379..90861 - 483 WP_014386536.1 GNAT family N-acetyltransferase Toxin
F11wdg_RS26160 (F11wdg_pA0090) 90852..91130 - 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
F11wdg_RS26165 (F11wdg_pA0091) 91249..91461 - 213 WP_004902255.1 hypothetical protein -
F11wdg_RS26170 (F11wdg_pA0092) 91569..91910 - 342 WP_004902257.1 hypothetical protein -
F11wdg_RS26175 (F11wdg_pA0093) 92740..93198 - 459 WP_014386535.1 hypothetical protein -
F11wdg_RS26180 (F11wdg_pA0094) 93851..94306 - 456 WP_001166628.1 Hg(II)-responsive transcriptional regulator -
F11wdg_RS26185 94492..95754 + 1263 WP_000608644.1 IS1380-like element ISEcp1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaCTX-M-14 / qacE / catB3 / blaOXA-1 / fosE - 1..221757 221757


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17662.45 Da        Isoelectric Point: 8.9130

>T237354 WP_014386536.1 NZ_CP092902:c90861-90379 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

>T237354 NZ_LR881940:197640-197747 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT237354 WP_004902250.1 NZ_CP092902:c91130-90852 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp

>AT237354 NZ_LR881940:c197592-197526 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBI1

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References